Study Of The Effects Of Prostaglandine_ 1 In Patients With Rheumatic Heart Disease Associated With Pulmonary Hypertension

Objective: to observe hemodynamic and alterations the levels of plasma ET, NO and CGRP after prostaglandin E1 (PGE1)administration in patients with rheumatic heart disease(RHD)associated with pulmonary hypertension. Methods:The 32 valve replacement cases with rheumatic heartdisease were collected and divided two groups: group A was 16 patients with pulmonary hypertension, group B was patients without pulmonary hypertension. Group C was16 cases who were normal controls. Group A, 20 cases whose pulmonary hemodynamic alterations were monitored with Swan-Ganz catheter, ET and CGRP level were determined by using radioimmunoassay, NO2-/NO3- (reflecting NO level) was altermined by copper coated with calmiucm reduction method. Results:The plasma both ET and NO level of patients with rheumatic heart disease were significantly higher than that of normal controls(Group C), the plasma CGRP level was on the contrary. The plasma ET level of group A was significantly higher than that of group B. The plasma level of ET had a significantly positive correlation with pulmonary arterial pressure. The hemodynamics and levels fo plasma ET, NO and CGRP took the significantly change after PGE1 in group B. Conclusion: ET, NO and CGRP might be involved in RHD by causing pulmonary hypertension and local vascular endthalium pertutarbation. PGE1 could play important roles in the perioperative valve replacement of RHD associated with pulmonary hypertension...