Determination Of Serum And Urinary Thyroid Hormones In Primary Nephrotic Syndrome

Objectives To study the changes of serum and urinary Triiodothy-ronine (T3), Thyroxine (T4) in children with acute and remission primary nephrotic syndrome (PNS) and the correlation between their levels and urinary protein, and serum albumin. Methods Radioim-munoassay (RIA), colorimetry, bromcresol green method were used to detect T3, T4, TSH, urinary protein, serum albumin, respectively. Results The serum T3, T4 of acute phase in PNS decreased, the serum TSH and urinary T3, T4 increased as compared with the controls (P<0.01,0.01,0.01,0.05,0.05). These parameters were normal in remission. The serum T3, T4 showed a positive correlation with the serum albumin(r=0.50, 0.45; P<0.05,<0.05)and a negative correlation with the urinary protein (r=-0.46, -0.79; P<0.05, <0.01). However, the serum TSH showed a positive correlation with the urinary protein(r=0.43, P<0.05) and a negative correlation with the serum albumin(r=-0.44, P<0.05). Conclusions These findings provides evidence of temporary hypothyroidism in the acute phase of PNS, partialy related with T3, T4 losing from urine.