| Objective: Hepatitis B virus(HBV) infection is a global health problem. China is a nation of high infection, the rate of people taken along HBsAg is 9.75%, and the rate of HBV infection is 57.63%. At present, there is no patent medicine to treat Hepatitis B(HB). Once one was infected by HBV, to clean the virus is very difficult. As contamination of HBV in environment is extensive, HBV's modes of transmission are diversify, and the preventive measures of break the mode of transmission can't make effect in the prevention of HB, the key to reduce infection of HBV is to protect susceptible people. Nowadays, the most operative method of control the HB is vaccination. But the investigation of recent years showed that after vaccination of HB, there have been 5-10% people who have no or not enough anti- HBs. Non-responsiveness become an important problem of HB prevention in the future. How to promote response rate of vaccination of HB, and make HB's harm lowest? The cause of non-responsiveness are many more, and it's mechanism of formation isn't completely known. So, we think about in many ways, study the possible cause of non-responsiveness with univariate and multivariate Logistic regression, and want to provide reference to solve the problem of HB. Methods: 1. 2 schools were chosen randomly sampling from the elementary andmiddle schools of FOSHAN city, in which 4072 students wereinvestigated.2.A11 objects were withdrawal 5ml, detected HBsAg, anti-HBs> HBeAg,anti-HBe, anti-HBc by ELISA, if anti-HBs is negative, detected by SPRIAagain.3.Among the students of anti-HBs negative(detected by ELISA), 300students were chosen randomly to have vaccination again(10micrograms, 0, 1,6months), and at 7 months, anti-HBs was detected by SPRIA.Results:l.The rate of HBVDNA is positive in those who were non-responsiveness is22.97%, and 5.8% in responsiveness (P<0.05).2.There were 813 whose anti-body was negative(detected by ELISA andSPRIA), the rate of non-responsiveness is 20.9%.3.In the univariate Logistic regression non-responsiveness associated withage (OR=1.222, 1.178-1.269), height (OR=1.029, 1.021-1.036),weight(OR=1.036, 1.028-1.044 X vaccination(OR=0.170, 0.125-0.232),vaccinated times (OR=1.051, 1.023 - 1.079), vaccinated place (OR=1.562,1.248-1.955), blood transfusion (OR=0.501, 0.280-0.898), dishwaredisinfections ( OR=1.376 , 1.075 - 1.761 ) , father hasn't vaccinated(OR= 1.359, 1.210-1.526), father hasn't anti-HBs after vaccination(OR= 1.324, 1.143 - 1.535), mother hasn't anti-HBs after vaccination(OR=1.356, 1.180- 1.558XIn the multivariate Logistic regression, the factors corning into the model were: age (OR-1.229, 0.0134-0.332), vaccination (OR=0.157, 0.074-0.332), dishware disinfection (OR=1.474, 0.951-2.283), father hasn't vaccinated (OR=1.364, 1.075- 1.725), mother has vaccinated(OR=0.771, 0.584-1.023 ).4.95%(285/300) students have vaccination with 3 doses, and 271 students' anti-HBs > 10MIU ml-1 (detected by SPRIA).Conclusion:l.The HBVDNA detected results indicate that HBV infection beforevaccination can't be neglect.2.The rate non-responsiveness in our investigation is 20.9%.3.Age, height, weight, vaccination, vaccinated times, vaccinated place,blood transfusion, dishware disinfections, father hasn't vaccinated, parentshaven't anti-HBs after vaccination associated with non-responsiveness in theunivariate and multivariate Logistic regression.4.The students whose anti-HBs was negative have received 3 doses HBvaccine and 95.1%(271 /300) developed anti-HBs. |
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