| The major pathophysiological mechanism of cerebral infarction is atherosclrosis ( AS). The risk and severity of cerebral infarction in-crease alone with aggravation of AS, therefore prevention and treatment of AS is the key to decrease occurrence of cerebral infarction. Hyper-tension diabetes hyperlipidemia current smoker and age are known risk factors for AS. These years many studies show that hyperhomocys-teinemia is an independent risk factor for AS and elevated homocys-teine(Hcy) level is related to degree of AS. Studies demonstrate that elevated Hey level can be reduced to normal by giving folate Vita-minB]2 and VitaminB6, which is very important to prevention and treat-ment of AS. At present, study in this field are few in our country. The purpose of this study is to observe plasma Hcy folate and VitaminB12 level of patients with crebral infarction analyse association between them and degree of carotid AS, so as to make clear that hyperhomocys-teinemia is a risk factor for AS.MethodsSelect 60 patients with cerebral infarction, male, age is from 60 to 75 years old. At the same time select 10 healthy subjects who came to outpatient department for physical examination as control group. Allsubjects have no cardiogenic embolism or hepatic renal thyroid dys-function , no tumor or psychosis history, no administration of vitamine B. Collect history of conventional risk factors such as hypertension di-abetes meclitus hyperlipidemia and smoke. Take notes of Blood Pres-sure and BWI. Collect fasting venous blood in the morning, measure plasma Hey folate vitaminB12 blood glucose blood lipid and creati-nine.Plasma Hey was measured with Flourescence Polarization Immu-noassay ( FPIA ) , American Abbott company supply IMx system and re-lated reagents. Folate and VitaminB12 were measured with electricoal chemical assay, Swiss Roche company supply Elecsys 1010 analyzer and related reagents. Check common carotid artery and internal carotid artery of both sides by LogiqV color doppler ultrosound apparatus, measure intima - media thickness (IMT) of artery percentage of inter-val diameter stricture and peak systolic velocity ( PSV ). According to degree of stricture,from light to heavy,devide all patients into A,B, C D group.ResultsResults show that there are not significant differences in age Bp BWI FBG Cr related diseases and smoke history among all groups. Plasma Hey in control group and A B C D group is respectively (10. 92 ?3. 51)μmol/L, ( 11. 74 ?2. 79) |xmol/L, (16. 42 ?3. 51) jjunol/L,(19.92?.55) jjunol/L, (41.58 ?18. 51) nmol/L. Along with aggravation of carotid artery stricture, Hey level increase. After SNK test,there are significant differences among control group and A B C D group (P <0. 05). Results also show that folate and vita-mmB12 decrease when Hey level increase and carotid artery stricture become worse, but only between A and D group the difference is obvi-ous (P <0. 05). Among 60 patients,24 with normal Hey level( < 15μLmol/L) ,36 with elevated Hey level ( ≥15|xmol/L) , which ac-count for 60% of patients with cerebral infarction. In control group, one subject with high Hey level, accounting for 10%. Folate in group of normal Hey level is (10. 55 ?. 11)ng/ml,while in group of ele-vated Hey level is (6.47 ?. 23) ng/ml, the difference between two groups is significant. VitaminB12 level in the two groups as above is re-spectively (500. 02 ?173. 91) pg/ml,(385. 78 ?147. 38)pg/ml,but there is no significant difference in two groups. In this study, TCHO TG,LDL - C increase when carotid AS aggravate, HDL - C decrease. But after statistical management, there is no obvious association be-tween carotid AS degree and plasma level of TCHO;TG;LDL - C or HDL-C(P>0.05).ConclusionResults show hyperhomocysteinemia is graded associated with ca-rotid AS. Plasma Hey level increase along with aggravation of carotid AS stricture, which is consistent with previous reports. Accompanying aggravation of carotid AS,plasma folate vitaminB12 level decrease,and the... |
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