Clinical Observation Of Effacy On Liposomal Albendazole Against Echinococcu Infections In 66 Cases

Objective: To assess the therapeutic effacy on liposomal albendazole against human echinococcosis so as to provide more evidence and theoretical basis for further clinical application. Methods: In a total of 66 patients with CE and AE, 56 cases CE (15 cases with multi-organ involved)were orally taken L-ABZ with dosage of l0mg/kg d, twice daily for 3-12 months.10 AE patients(3 cases with multi-organ involved) were given the same dosage for 3-12 months.Therapeutic effect and reliability for L-ABZ have been evaluated by imagins (US,CT,MRI),clinical manifestations,labortory tests and followed up routinely from 3 to 24 months. The common therapeutic standards were classified as cure, effectiveness, partical effectiveness and noneffectiveness. Effects of L-ABZ were analyzed for the types of simple cyst and multiple daughter cyst.At the same time,postive rate about subjective symptoms and labortory tests were regarded as standard of side-effects of L-ABZ. Result: In total of 66 patients.20 cases(30.3%) were cured, 29 cases(43.9%) as effective, 10 cases(15.1%) as partial effective, 7 cases (10.6%) as noneffective,The total effective rate was 89.3%.By analyzing,the effects of L-ABZ for type of simple cyst(CE)) is more sensitive than type of multiple daughter cyst(CE2) in cure of rate, however, there were not different between CE] and CE2 by contrasting thetotal effective rate,same as the patients who episode firstly and secondly.In AE patients,over half were better treated. In observation of side-effects, postive rate about subjective symptoms and labortory tests wrere respectively 13.6% (9/66) and 12.1% (8/66) , disorder of digestive system and abnormality of liver function were common,however,these symptom and abnormality would ameliorate,so,the course of treatment have not been terminated. Conclusion: L-ABZ can be considered as a new furmulation which had better effective for the treatment of human echinococcosis,and its side-effects is slight,thus,it showed more promising for clinical purpose in future.