| YiXin capsule is a effective compound herbal pharmaceutics devised and manufactured meticulously to cure the ischemic heart disease, Which summarized many experts' clinical experience and had repeated experiments for many years. Now YiXin capsule has been approved by Nation medicine administer bureau and entered III clinic. To study further its definite mechamisms of action, We selected the acute myocardial ischemia model of rabbit as study object and TongXinLuo capsule as positive control-medicine, applied the advanced means of biochemistry and pathomorphology to carry on correlative experimental research. The results indicate that the myocardial ischemia model of rabbit induced by the desending anterior branch of coronary ligation is similar to that of mankind. YiXin capsule can improve the Pathomorphology and ultrastructure of cardiac muscle of myocardial ischemia rabbit, thereby, confirm that YiXin capsule has exactly function to prevent and cure the myocardial ischemia; YiXin capsule can also heighten the NO and NOS content of blood serum and cardiac muscle tissue of myocardial ischemia model, Wiche poins out that YiXin capsule can achieve preventing and curing myocardial ischemia through protecting vascular endothelial cell and improving endothelial function. Its curative effect is priorto model-group obviously and similar to TongXinLuo group. It suggests that the medicina has definitly curative effect on myocardial ischemia and increases the NO and NOS content of blood serum and cardiac muscle tissue, Which is probable one of the mechamisms of action. |
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