Clinical Study On Risk Factors For Asymptomatic Cerebral Arterial Pathological Changes In Patients With Diabetes Mellitus

Objectives: To analyze the risk factors correlation of asymptomatic cerebralarterial pathological changes in patients with diabetes mellitus (DM). To collect cases into our databank, for a follow-up study to concerns the relationship between asymptomatic cerebral arterial pathological changes reflected with TCD and stroke in patients with diabetes mellitus.Methods: Inpatients with diabetes mellitus who had been examined withtranscranial Doppler sonography (TCD) were included in this study. The exclusion criteria were mainly any kinds of stroke and stroke history, or other intracranial disorders. All correspondent clinical information including detailed history, laboratory data, and TCD results was collected. After analyses of TCD results, two kinds of self-made parameters, Rate of Artery Abnormality (TCD-RAA) and TCD Semi-Quantitative Score (TCD-SQS) were used to reflect the asymptomatic cerebral arterial pathological changes. The correlations of TCD-RAA, TCD-SQS to age, duration of disease, blood pressure, hyperlipidemia, hyperuriemia, etc, were statistically analyzed with SPSS 11.0 software.Results: 1. No relation of sex to TCD-RAA and TCD-SQS was found. TCD-RAAwas lineally correlated to age; among them the correlations of age to TCD-RAA in carotid artery system and the rate of increased flow velocity arteries (RIVA) were more obvious. 2. TCD-RAA was significantly coorelated to duration of DM. With the prolonging of duration of DM, the TCD-RAA of MCA and OA in youth-middle aged diabetics, TCD-RAA of ICA and VA in old aged diabetics signifivantly increased. 3. TCD-SQS was lineally correalted to age and duration of DM. 4. Correaltions of TCD-RAA to serum levels of triglyceride, low density lipoprotein and uric acid were evident, and linear correaltions of TCD-SQS to serum level of low density lipoprotein and diastolic blood pressure were found.Conclusions: Rate of Artery Abnormality (TCD-RAA) and TCDSemi-Quantitative Score (TCD-SQS) can reflect the features of asymptomatic cerebral arterial pathological changes of DM . Age, duration of DM, elevated serum levels of Triglyceride, low density lipoprotein, uric acid and diastolic blood pressure are risk factors for asymptomatic cerebral arterial pathological changes of DM. The features of asymptomatic cerebral arterial pathological changes in diebetics reflected with TCD-RAA and TCD-SQS are in accord with the clinical features of strok to some degree, indicating that asymptomatic cerebral arterial pathological changes of DM reflected with TCD may be the paramaters to predict strok in diabetics.