Expression And Signifiance Of Glycodelin In Synovial Sarcoma

Objective: To observe the expression and distribution of Glycodelin in synovial sarcoma and discuss its significance and relationship with pathologic subtype.Methods: Thirty-six specimens of synovial sarcoma were collected between November 1986 and December 2001, and divided into three group according to HE. The expression of Glycodelin, EMA and E-cadherin was assessed by immunohistochemistry (SP) in every pathologic subtype.Results: The expression rates of Glycodelin protein in biphasic, monophasic epithelial. monophasic fibrous synovial sarcormas were 93.3%, 100% and 22.2% respectively. Glycodelin was mostly localized in cytoplasma of epithelial cells, some were seen in lumina of glandularstructures; the component of the spindle cell and the non-glandular areasdidn't show reactivity with antibodies to glycodelin. There was a positivecorrelation between Glycodelin and EMA, E-cadherin.Conclusion: The high expression of Glycodelin in the glandular areas ofsynovial sarcoma play an important role in the determination ofstroma-to-epithelium maturation.