Effect Of Dingchuantang On IgE And IL-4 Serum Of Rats Of Bronchial Asthma

Bronchial asthma, called asthma for short, is a chronic inflammation of bronchia. Many inflammatory cells such as mast cell, eosinophil, T cell etc. participate in the inflammatory reactions. The main changes in pathology is inflammatory reactions of bronchial mucous membrane, hyperkinesia of bronchial smooth muscle and a reversible block of bronchia caused by secretion. During the outbreak of asthma, IgE produced by immunocyte is the key of the disease when the immune system activated by allergen. Inflammatory reactions of respiratory tract is the base of hypersensitivity. Many inflammatory cells such as neutrophil, macrophage, eosinophil (Eos), T cell and B cell etc., inflammatory medium and cytokine participate in the inflammatory reactions.In therapeutics, it is realized that the method that use P -receptor activator, aminophylline and anti-cholinornimetic drugs etc. to relieve hyperkinesia is not all around. It is the essential measurement that use corticosteroid drugs treating the hypersensitive inflammation to prevent the onset of asthma. But the long term use will lead to the sthenic symptom of corticosterone function. Inhalation will lead to the side effect as hoarseness, thirst, infection of Candida and drug resistance. Recently, research shows that, the incidence and mortality of asthma are increasing in world wild. Therefore, using Dingchuantang to treat asthma have the practical significance in clinic through the function of immunity regulating under the guidance of traditional Chinese medicine theory.In order to explore the mechanism and effect of Dingchuantang in treatingimmunity of bronical asthma and cooperation with aminophylline, the experiment was developed. The rat model of bronchial asthma was built up. The effect of Dingchuantang, aminophylline and both of them on the rat of bronchial asthma were observed, and total cells in the bronchoalveolar lavage fluid (BALF), eosinophils(Eos) count, IgE and EL-4 lever were tested. Results show that: Bronchical asthma model group compared with the control group, IgE and IL-4 serum lever(P<0.01) in the asthma group showed higher than those in the control group; The group of high dose Dingchuantang compared with the model group, decreasing the total cell,Eos count, IgE and IL-4 lever (P<0.01); There is cooperation between Dingchuantang and aminophylline (PO.01).It can be concluded that, Immunological abjustment of Dingchuantang in treating bronchial asthma was finished by regulating the immune function, resisting IgE and IL-4 lever and decreasing Eos count. Both Dingchuantang and aminophylline increased the function of treating bronchial asthma. There is cooperation between Dingchuantang and aminophylline, and the both application will increase the function of treating asthma. It not only can relieve the smooth muscle of bronchia, but also can regulate the immune function through suppressing immunocyte to producing IgE, IL-4 etc. Therefore, it can treate the inflammatory reactions of respiratory tract, decrease the hypersensitivity of respiratory and supress the asthma. The experiment provide a evidence on molecular pharmacology for clinic in treating asthma, but the detail is waiting for more research.