| Objective: To explore the clinical effect and the mechanism of treatment of chronic idiopathic thrombocytopenic purpura(CITP) by Zhi Dian Prescription Methods: 38 patients were randomed dividing treatment group 26 cases and control group 12 cases. The control group was adopted with prednisolone,and the treatment group was used with Zhi Dian prescription and prednisolone. The treatment course of both groups was 6 months. Using immunologic indexes to explore the mechanism. Results:The markedly effective, improved and total effective rate of the treatment group were 30.77%, 23.08% and 84.62%, while those of the control group were 8.33%, 16.67% and 58.33% respectively, the difference between the two groups was significant (P<0.05). The effect of the treatment group was better than the control group in platelet count restoring,hemorrhagic symptoms improving and effect initiating (PO.01). Immunologic test showed that the humoral and cell immune function as well as platelet function were abnormal in CITP patients. The functions were improved after treatment, and the effect of the treatment group was significantly superior to that of the control group (PO.05~0.001). Conclusions: Zhi Dian prescription is reliable in treating CITP clinically.Its mechanism might be better due to its selective suppression of humoral immune function, bi-directional regulation of cell immune function and recovery of platelet function. |
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