Effects Of Factors And Relative Mechanisms On Biological Behaviors Of Human Ovarian Cancer

Ovarian cancer is a leading fatal cause of gynecological malignancies . Its therapeutic failure and poor prognosis is mainly due to the difficulty for early diagnosis, the metastasis and drug/radio resistance . Therefore, it is imperative to improve the early diagnosis, the effective control for overproliferation, metastasis and drug/radio resistance. This study is focus on factors and relative mechanisms which affect the biological behaviors of oncogenisis and resistance of human ovarian cancer. 1. Expressions and significance of CD4O, VEGF, CyclinDl, Gelsolin in human ovarian cancer. Recent studies have suggested that, human malignant oncogenesis is a intricate process which is involved in multiple 6 ~Th~2 ~ factors and mechanisms . Present studies have proven that most of the human malignant cells exhibit a series of molecules deregulations, including CD4O, VEGF, CyclinD 1, Gelsolin. These aberrant molecules not only affect the proliferation and migration capcity of tumor cells, but also regulate their cell cycle progression and apoptosis . Besides, these factors may play critical roles in the diagnosis, prognosis and treatments of human malignant tumors. However, the roles of these molecules in ovarian cancer need further studies. On the basis of detecting the expressions of CD4O, VEGF, CyclinDl and Geiso]in in several ovarian cancer cell lines in vitro, their expressions in different types of ovarian tissues, including normal tissues, benign tissues and malignant tissues were further examined by inimunohistochemical methods. The correlations Of their overexpressions 憌ith clinical stages, histological types, grades and lymphoid node metastasis of ovarian cancer were also investigated. Our results suggest that: (1 )The expressions of CD4O, VEGF, CyclinD 1 and Gelsolin in malignant tissue were much higher than those in normal and benign ones, with significant statistical difference (P