Expression Of Intercellular Adhesion Molecules-1 During Pneumonectomy Undergoing Surgery And General Anesthesia

【Background】: Intercellular adhesion molecules-1 (ICAM-1) has been shown to play important roles in the acute lung injury and the lung inflammation.【Objective】: The aim of this study was to investigate expression of soluble(s) ICAM-1, and the effects of dexamethasone on serum sICAM-1 levels during Pneumonectomy undergoing anesthesia to observe the possible activation effects of dexamethasione. 【Method】: In a randomized ,double-blind study design. Twenty smoking patients with lung cancer undergoing elective Pneumonectomy were randomly divided into control group (I, n=10) and dexamethasone group (II, n=10). The patients were treated with 0.002mg.kg-1.min-1 of dexamethasone during surgery in II group. Arterial blood of samples were obtained before anesthesia , one hour after incision , end of surgery, twenty-four hours and forty-eight hours after surgery to measure the serum concentrations of sICAM-1. Total white blood cell counts and differentials were determined before and 24 , and 48h after surgery.【Result】 : In I group, the serum levels of sICAM-1 significantly increased from baseline (188.50±65.45ng/ml ) to 409.30±79.50ng/ml (p<0.01) at one hour after incision ,and 358±74.70ng/ml at end of surgery(p<0.01), and 430.60±95.60ng/ml,512.70±94.50ng/ml at 24h and 48h after surgery(p<0.01). However, in the II group, the serum levels of sICAM-1 increased from baseline (180.67±61.50ng/ml) to 301±69.70ng/ml at 48h after surgery. But ,the serum levels of sICAM-1 increased significantly less than that of in the I group(p<0.05). The total white cell and neutrophils significantly increased at 24h and 48h after surgery in both groups. Compared with I group at 48h after surgery ,the neutrophils decreased in the II group (p<0.05). No severe postoperative complication was observed.【Conclusion】: We conclude that the expression of sICAM-1 significantly increases and dexamethasone suppreses the expression of sICAM-1 During Pneumonectomy Undergoing Surgery and General Anesthesia.