Experimental Study Of Taxol Lnhibiting Neointima Formation After Stent In The Canine Femoral Artery

Objective To evaluate the efficacy, safty and feasibility of Taxol inhibiting smooth muscle cell accumulation and neointima formation after stent in the canine femoral artery by systemic and local delivery Methods 12 dogs were randomly assigned to two groups(Taxol or control group), Taxol group implanted stents in both femoral arteries, one side(Tt) local delivery of Taxol (20m1,20 p. mol/L, 5atm,2 ininutes)with a porous balloon ;the other side (TDlocal delivery of vehicle only(0.9% NaC1 solution);then intraveonous drip of taxol (1. 5mg/kg) ;control gurop(C) implanted stent in one side of femoral arteries, local delivery of vehicle only(0.9% NaCl solution) After 8?0 weeks , the femoral artery angiography was performed,pathological sections of femoral arteries were observed and the area of intima ,media and residual lumen was calculated, the extent of stenosis was determined as follows: %ES4A xlOO/IELA0 Results The extent of stenosis in local Taxol delivery group was signficantly reduced compared with control group and systemic Taxol delivery group(0.55?.12 vs 0.84?.09.~. 0.83 ?0.09 ,p0.0001).N0 significant difference was found between the latter groups. Conclusions Local delivery of Taxol(2Oml,20i,tmol/L, Satm,2 minutes) can significantly reduce neointima formation and extent of 4 stenosis in canine femoral artery after stent implantation, but systemic delivery of Taxol (1. 5mg/kg) has no effect.