Protective Effects Of A Emulsion On Adriamycin - Induced Myocardial Injury In Mice And Its Mechanism

Drug A is not only a material of lipid and similar with vitamin, but also an important antioxidant and unspecific immune intensifier. This study is to investigate the protective effect of Drug A against adriamycin-induced cardiotoxicity and its mechanism. The cardiotoxicity was induced by intraperitoneal injection of adriamycin (ADM) at a single dose of 20 mg·kg-1 in mice. The health conditions, electrocardiogram, activity of SOD, CK, MDA and LDH in tissue homogenate, the ultrastructure and the expression of p53 protein in cardiac tissue of mice were observed to evaluate the protective activity.The results indicated that compared with normal control group, ADM decreased the amplitude of ECG’s R wave, increased the incidence of arrhythmia, injured the myocardial ultrastructure, increase the activity of CK, MDA and LDH, decrease the activity of SOD, and increased the expression of p53. Compared with ADM group, the Drug A restored the amplitude of R wave, decreased the incident of arrhythmia, decreased the levels of CK, MDA and LDH, increased the activity of SOD and also decreased p53 express.Summarizing all the experimental results, Drug A showed protective effect against adriamycin-induced cardiotoxicity. The mechanism may be involved in its antioxidant activity, inhibiting free radical and apoptosis. This study provided the experimental basis to the clinical application of Drug A emulsion as a cardiac assistant drug in the tumorous treatment. However, the mechanisms accounted for the effects of Drug A’s antioxidant activity deserve further study.