A Systematic Review Of Traditional Chinese Medicine In The Treatment Of Acute Exacerbation Of Bronchial Asthma

Purpose:To evaluate the efficacy and safety of traditional Chinese medicine(TCM)for acute exacerbation of bronchial asthma.Material and method:According to the search strategy,from the Chinese Biomedical Literature Database(CBM) 、 electronic searching China National Knowledge(CNKI)、Chinese Science and Technology of Journal Full-text Database(VIP)And Wanfang data base retrieval;Filter on the initial document,and eventually incorporated into the document data extraction;Cochrane bias risk assessment table incorporated into the methodological quality assessment of the literature.Ren Man5.3 software was used for data analysis(Meta analysis), all data retrieval time from construction until December 31, 2014, with its acute episode of bronchial asthma treated by TCM literature evaluation system.Results:1.According to into standard,Participants included 40 randomized controlled trials, which has 1 items research description has random distribution method(used random digital table method); 40 items research are not description distribution programme hidden; three research selection blind method,(2 items research used single blind "16" "38", and 1 items research used double blind "22" of method); 3 items research results data full; 40 items research are not selective report results; 40 items research no other partial leaned.2.Effects of asthma treated by TCM intervention(1)Total efficiency, Symptomatic efficacy: a total effective OR 2.60[95%CI(2.11,3.21)],P<0.00001.Symptomatic efficacy OR2.58[95%CI(1.27,5.27)],P=0.009,the difference was statistically significant.(2) The lung function FEV1, PEF, PEFR, FEV1%, FVC, MEF25, MEF50, Seven areas were evaluated. FEV1 MD value is 0.24[95%CI(0.14,0.35)],P<0.00001. PEF SMD value is 0.46[95%CI(0.14,0.79)],P=0.005. PEFR SMD value is 0.42[95%CI(0.15,0.69)],P=0.002. FEV1% MD value is 4.29[95%CI(1.96,6.62)],P=0.0003. FVC MD value is 0.34[95%CI(0.26,0.43)],P<0.00001. MEF25 MD value is 0.07[95%CI(0.00,0.14)],P=0.04. MEF50 MD value is 0.16[95%CI(0.05,0.26)],P=0.005. The difference was statistically significant.(3) In peripheral blood t-cell subsets(CD4, CD8, CD4/CD8 three aspects for analysis),6-keto-PGF1α, IFN-γ, EOS is evaluated. CD4 MD value is-2.16[95%CI(-3.96,-0.36)],P=0.02. CD8 MD value is 2.63[95%CI(1.64,3.63)],P<0.00001. CD4/CD8 MD value is-0.20[95%CI(-0.36,-0.03)],P=0.02. 6-keto-PGF1 a SMD value is 0.42[95%CI(0.05,0.79)],P=0.03. IFN- γ SMD value is 1.42[95%CI(0.16,2.69)],P=0.03.EOS SMD value is-0.78[95%CI(-1.40,0.17)],P=0.01. The difference was statistically significant.(4)Integration of TCM syndrome and serum Ig E,CD3,ECP,IL-5,SIL-2R,IL-4,TXB2 P>0.05,No statistically significant differences.Conclusion:TCM treatment of bronchial asthma at acute attack stage has a certain effect, 40 articles in quality due to the lower, can affect the result, So in the future should be more scientifically rigorous clinical research methods,improving the quality of documents, choose more rigorous clinical "samples", "Center", "randomized", "Standardization" trial, to provide additional data, enhance the reliability and accuracy of the data, and improve the quality of research of traditional Chinese medicine and clinical.