A Systematic Review Of The Intervention Of Traditional Chinese Medicine (metformin Control) In The Early Stage Of Diabetes Mellitus

Part One:Literature Study:Overview the intervention of pre-diabetesWith the incidence of diabetes increasing year by year,people pay more attention to diabetes prevention.The study found that the intervention in pre-diabetes could effectively reduce the incidence of diabetes,which had great significance on the prevention of diabetes and the complications. Numberous clinical trials had discussed the efficacy and safety of the intervention programs.Lifestyle,medicine and Traditional Chinese Medicine were all proved to be clinically significant on diabetes prevention and treatment.However, the current problem now clinical doctors facing is how to choose individualized intervention to different patients.Based on lots of reading,we make a literature study about the methods which now have been used in clinic to intervent pre-diabetes.According to the outline,we review the efficacy of those three intervention stuides before. By the summary,the effectiveness is confirmed further more.And it provides preliminary literature evidence to further research.Part Two:The Systematic Reviews for the Traditional Chinese Medicine (Compared with Metformin) in Intervention of Pre-diabetesObjective:To evaluate the efficacy and safety of Traditional Chinese Medicine compared with metformin in intervention of pre-diabetes.Methods:According to requirement to systematic review of Cochrane Collaboration,we conducted electronic searches in the Cochrane Library, PubMed, CBM, CNKI, VIP, etc.Then the data analysis was performed using RevMan5.2software.Results:We selected20RCTs, including1542cases of pre-diabetes. The results:(1)Compared with metformin,the TCM had better effecacy in improving clinical symptoms of pre-diabetes;(2)Be the same role in improving PG,HOMA-IR,HOMA- β,total efficiency,disease outcome,LDL,WHR;(3)Compared with metformin,the TCM had better effecacy on FPG,HbA1c,insulin secretion,glucagon,TC,TG,HDL and BMI;(4)Compared with metformin,the TCM causes lower frequency of adverse reactions significantly;(5)The Traditional Chinese Medicine also can lower the level of BP,FA and CRP.Conclusion:The Traditional Chineses Medicine could lower the level of FPG,lipids and BMI.It could improve insulin level and glucagon level.And also it could improve the symptoms of pre-diabetes obviously.Meanwhlie,the TCM caused less adverse reactions.The TCM had significance on preventing diabetes in clinic.