| In modern medical science, hyperlipidemia is the most common form of dyslipidemia. The abnormally elevated levels of any or all lipids are usual antigens of diagnostic standard, and it is commonly seen in elderly. Along with the improvement of living standards and rapid development of economy, he prevalence of hyperlipidemia rises gradually, and there is a tendency to young people for patients with hyperlipidemia in age. In modern medical science, hyperlipidemia is regarded as a modifiable risk factor for atherosclerosis, cardiovascular disease and cerebral apoplexy. Effective control of lipid level can decreases the incidence of cardiovascular disease and mortality. Therefore we need to pay close attention to it in daily life. In Chinese medical science, with the change of the dietary structure and life rhythm, the overeating, lack of exercise, sedentariness and the choice of cold and raw food are commonly seen among people. While these habits can easily hurt the spleen and stomach, the spleen and stomach are the valley of foodstuff, the origin for qi-blood production, the pivot of zangfu and meridian, the root of acquirement. The above habits can cause the a pathological change of qi in ascent and descent, the body fluid can turn into shi-zhuo due to its irregular distribution. As a matter of fact, we can classify the cause of hyperlipidemia into shi-zhuo.In reference to treatment, the western medicine work fast and have accurate efficacy. However, these medicine have a certain degree of adverse reactions, such as toxicity in live, nervous system and muscle. The risk of serious adverse reaction are dependent to the dosage. The fibrate and nicotinic acid will produce gastrointestinal discomfort, liver and kidney damage, and easy to rebound after the drug was stopped, need lifelong medication. About the systematic evaluation of the efficacy and safety of Chinese traditional medicine, only the Xue Zhi-kang capsule had verified by evidence-based medicine. But the capsule contains 13 kinds of natural Monacolin which is a statin homologue. So in order to seek an effective non-drug therapy in the treatment of hyperlipidemia, we conducted clinical research of a li-shi-jiang-zhi fumigation treatment to provide a theoretical basis for the popularization and applic-ation.In this research, the Chinese herbal fumigation promotes lipid discharge via the skin absorption and penetration, which won’t cause stimulation to the oral mucosa, gastrointestinal tract and gastrointestinal and burden the live and kidney. This therapy has good curative effect for the patients who have the shi-zhuo-bi-zu as the main syndrome types of hyperlipidemia, and it also make overall adjustment to the patients themselves. Objective:To investigate the improvement of outcome measures of the patients with HLP who were under the treatment of traditional Chinese herbal li-shi-jiang-zhi fumigation and objectively assess the efficacy and safety of the treatment. To provide clinical basis for the exploration and promotion of the new non-drug therapy of hyperlipidemia.Methods:70 patients with primary hyperlipidemia of shi-zhuo-bi-zu syndrome were randomly divided into treatment group (fumigation therapy group, n=35) and control group (western medicine group, n=35). Fumigation therapy group were given Chinese herbal fumigation (three times a week in the first four weeks; two times a week in the last four weeks).The fumigation lasts 15 to 20 minutes and the temperature is 40 to 45 degree centigrade. The control group is given atorvastatin (20mg/d) for eight weeks. Record the variation of blood lipid levels (including TC,TG,LDL-C,HDL-C) and TCM syndromes before and after the course of the treatment. Observe the function of liver and kidney and concentrate on the adverse reactions during the treatment. After the clinical observation, process the data and make detailed statistical analysis.Results:The levels of TC,TG,LDL-C decrease while the level of HDL-C increase after 8 weeks of treatment in fumigation group and there is a statistically significant difference in TC,TG,LDL (P<0.05). The total clinical effective rates were 88% in test group and 92.6% in control group, there is no significant difference (P>0.05). The syndromes of TCM and the integral of syndrome of TCM were both descended. In test group, the TCM syndrome of headache, sleepiness, Abdominal fullness, physical heaviness, sticky mouth and discomforting evacuation descended obviously(P<0.05). The total effective rates of TCM meliorating symptoms were 80% in test group and 55% in control group.Compared between the two groups, there is a statistically significant difference (P<0.05), which shows that the test group has a better curative effect on improving syndromes of TCM. During the clinical trial, there happened no obvious treatment-related adverse event.Results:Li-shi-jiang-zhi fumigation treatment can effectively relieve clinical TCM symptoms, reduce levels of blood lipid, there is no obvious toxic side effects and adverse reactions. It is a safe, and effective external treatment for the HLP. |
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