Clinical Observation On The Treatment Of Uterine Leiomyoma With Increasing Trend Of Guizhi Fuling Pills

Objective:Observe the clinical curative effect and safety of cassia twig tuckahoe pills to add and subtract treatment with growth trend of cold accumulation-caused blood stasis type of uterine fibroids.Methods:Clinical selection in August 2013 to December 2014 in China academy of traditional Chinese medicine Guang’anmen hospital gynecological clinics, met inclusion and exclusion criteria, the growth trend of patients with uterine fibroids of cold accumulation-caused blood stasis type, on the basis of cassia twig tuckahoe pills plus rhizoma zedoariae, notoginseng party with add and subtract in the treatment of six menstrual cycles, observing the efficacy and safety. Observation indexes included:(1) fibroids on growth volume per month of pre-treatment and post-treatment; (2)the uterine and fibroid volume of patients before and after treatment; (3) before and after treatment, the scores of menstrual period situation and menstrual symptoms, at ordinary times symptoms statistics; (4) serum levels of estradiol (E2) and progesterone (P), follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), prolactin (PRL) of pre-treatment and post-treatment. Safety indicators: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) of pre-treatment and post-treatment. Using SPSS17.0 software for statistical analysis, measurement data with mean+standard deviation (x±s)said, count data expressed in the proportion (%), the paired-sample T test or Wilcoxon.s signed rank test were respectively adopted for statistical analysis.Results:1. After the treatment, patients, fibroids on growth volume per month than pre-treatment significantly decreased (P< 0.01). Uterine volumes of 63.9% patients were reduced, and the average volume of uterus compared with pre-treatment had significant difference (P< 0.01). fibroid volumes of 58.3% patients were reduced, but the average volume of fibroids had no obvious difference compared with pre-treatment (P> 0.05).2. After the treatment, the scores of the menstrual cycle and menstruation compared with pre-treatment had no significant change (P> 0.05), the scores of menstrual blood volume menstrual blood clots and menstrual waist pain were lower (P< 0.05), the scores of the lower abdominal pain, cold in the lower abdominal and premenstrual breast distending pain significantly reduced than pre-treatment (P< 0.01).3. After the treatment, the symptoms of irritability and bad temper, moodiness, fear of cold, fatigue, dry mouth, feverish sensation in palms and soles, frequent micturition were improved, the extinction rate were 46.2%,88.2%,63.6%,88.2%,72.0%,62.5% and 77.8%.4. The female hormone levels before and after the treatment were in normal range, both compared with no significant difference (P> 0.05).5. The ALT and AST levels before and after the treatment were in normal range, which shows no significant change (P> 0.05). Conclusion:1. Cassia twig tuckahoe pills to add and subtract have the role of blocking uterine fibroids growth.2. Cassia twig tuckahoe pills to add and subtract have improve menstrual symptoms and effects.3. Cassia twig Tuckahoe to add and subtract have no bad effect on liver function, and possess a certain security.