Clinical Study Of Four Topical Drugs For The Treatment Of EGFRIs Skin Dry

This thesis consists of two parts:a literature review and a clinical observation.The first part is the literature review, the first review discussed the incidence, manifestations, laws of occurrence, evaluation and classification, the mechanism, prevention and treatment of the epidermal growth factor receptor inhibitors(EGFRIs)associated side effects of the skin, as well as traditional Chinese medicine’s understanding and treatment methods and other related aspects regarding to this side effect. The second review diseased the pathogenesis, clinical manifestation, understanding of traditional Chinese medicine, TCM etiology and pathogenesis, treatment and other convenient for common diseases with dry skin symptoms;The second part is clinical research.Objective:To compare the clinical effects and the safety of four kinds of drugs, such as recombinant human epidermal growth factor gel breast, vitamin E, "mostening dryness cream", urea ointment. As a Preliminary experiment for further study.Methods:Adopt themselves before and after the contrast method, select 10 cases are treated with epidermal growth factor receptor inhibitors during different degree of symptoms of dry skin of malignant tumor patients. Each person at the same time in the application of four limbs for external use drugs, twice a day; For an observation period, 14 days after the end of the observation period, jointly by two doctors determine the objective indicator; Then judging the curative effect by the participants at the same time. Observation, dry skin, skin desquamation, peeling, skin chapping, itchy skin changes before and after the treatment; Judgment of 4 kinds of durgs’efficience and safety.Results:1、Recombinant Human Epidermal Growth Factor Gel’s shortest time of symptoms relieving was 4 day and the longest was 10 days, and it has an average of 7.40 ± 2.12 days and the mid-time is 7.50 days. The best effect was mproving chapped skin. It was comfortable and convenient, but maintain the moisturizing effect was worse, need to improve the time of better form.2、Vitmin E Cream’s shortest time of symptoms relieving was 3 day and the longest was 10 days, and it has an average of 5.60 ± 2.37 days and the mid-time is 5.0 davs3、" mostening dryness cream" s shortest time of symptoms relieving was 2 day and the longest was 7 days, and it has an average of 4.80 ± 1.54 days and the mid-time is 5 days; the best effect was in the treatment of dry skin and itching skin, moisturizing effect was good, but the comfort and convenience were poor;4、Urea ointment’s shortest time of symptoms relieving was 7 day and the longest was 14 days, and it has an average of 10.30 ± 2.31 days and the mid-time is 10.5 days; in the improvement of EGFRIs intreatment of skin toxicity have certain curative effect, the overall effect was poor,but convenient.Conclusion:The four kinds of medications all could improve EGFRIs related dry skin symptoms in different degree,Each had advantages and disadvantages of four kinds of drugs in the treatment.