Expression Of NPM And Vimentin In Gastric Carcinoma And Its Clinical Significance

Purpose:To investigate the expression of NPM and Vimentin in gastric cancer and to evalue their relationship with clinical characteristics and prognostic significances.Methods:We detected the expression of NPM and Vimentin of113cases of gastric cancer tissues by immunohistochemistry. We deploy χ2test to analyze the relationship between the expressions of NPM or Vimentin and clinical factors, and use univariate and multivariate analysis in Cox hazard model to assess their prognostic significances.Results:The expression of NPM has significant statistical significance with tumor depth (P<0.001), lymph node metastasis (P<0.001), TNM stage (P<0.001) and recurrence or distant metastasis (P=0.02). Comparely, Vimentin expression were correlated with TNM stage (P=0.03) and recurrence or distant metastasis cases (P=0.03). The expression of vimentin and NPM was significantly related to a shorter postsurgical survival, independently of gender and histological differentiation, and was a more powerful predictor of outcome than the age, tumor depth, lymph node metastasis and TNM stage (HR:2.243for NPM and3.218for vimentin vs HR:2.042for age;1.493for tumor depth;2.132for lymph node metastasis and1.960for TNM stage).Conclusions:The expressions of NPM and Vimentin in postsurgical gastric cancers both have significant relationships with postsurgical recurrence and a shorter survival, furthermore, they are independent prognostic factors and more powerful predictor of poor outcome than other clinical characters.