To Investigate The Correlation Between Serum HBV-DNA Load And The Risk Of HCC Or PH Patients

Objective: We investigated whether the surgical risk of patient with hepatocellularcarcinoma who were at high levels of serum HBV-DNA loading.Methods: As a retrospective study, we collected these data from January2008to August2013at hepatobiliary-pancreatic surgery center, of the affiliated hospital of university ofelectronic sciences and technology. We assigned74patients with HBV-related HCC whowere being treated with surgery. The patients were divided into three groups according totheir serum HBV-DNA loading levels, such as low-replication group, middle-replicationgroup, and high-replication group. Also, we tested the patient’s liver function1day beforesurgery, and at day1, day3, day7after surgery, respectively. Meanwhile, the postoperativecomplications, hospital stay time, and serum HBV-DNA levels were also collected.Results: There were no significant differences (P>0.05) among three study groups withrespect to any other factors as to patient’s age, sex, Child-Pugh score, type of surgery,tumor size, hilar clamping time, operative time, bleeding, blood transfusion volume, aswell as preoperative factors as ALT, AST, TBIL. However, there were significantdifferences (P<0.05) in comparing to patient’s serum HBV-DNA level among the threegroups: the higher HBV-DNA loading had higher level of ALT and AST on the day1, day3, and day7after surgery. ALT and AST had the highest level at day1following thesurgery. There were significant differences of levels of ALT and AST between the threedifferent replication group (P=0.024and p=0.042, respectively), but no differences on day 3and day7. But in the highest group, ALT and AST had a slowly decline curve and alonger hospital stay time (P<0.05). With respect to postoperative complications, the overallcomplication rate was14.86%(11/74),20.0%(5/25) in the highest-replication group,14.81%(4/27) in the middle-replication group, and9.09%(2/22) in the low-replicationgroup, respectively.Conclusion: The high level of HBV-DNA has more complications, a longer hospital staytime and high levels of AST and ALT after surgery. It suggests that keeping a low level ofHBV-DNA during perioperative period would reduce the risk of surgery for patient withhepatocellular carcinoma. Objective: We investigated whether the surgical risk of patient with portal hypertensionwho were at high levels of serum HBV-DNA loading.Methods: As a retrospective study, we collected these data from January2008to August2013at hepatobiliary-pancreatic surgery center, of the affiliated hospital of university ofelectronic sciences and technology. We assigned41patients with portal hypertension inend-stage liver disease who were being treated with surgery. The patients were divided intothree groups according to their serum HBV-DNA loading levels, such as low-replicationgroup, middle-replication group, and high-replication group. Also, we tested the patient’sliver function1day before surgery, and at day1, day3, day7after surgery, respectively.Meanwhile, the postoperative complications, hospital stay time, and serum HBV-DNAlevels were also collected.Results: There were no significant differences (P>0.05) among three study groups withrespect to any other factors as to patient’s age, sex, Child-Pugh score, type of surgery,spleenic size, esophageal and gastric varices, operative time, bleeding, blood transfusionvolume, as well as preoperative factors as ALT, AST, TBIL. However, there weresignificant differences (P<0.05) in comparing to patient’s serum HBV-DNA level amongthe three groups: the higher HBV-DNA loading had higher level of ALT and AST on theday1, day3, and day7after surgery. ALT and AST had the highest level at day1following the surgery. There were significant differences of levels of ALT and ASTbetween the three different replication group (P=0.038and p=0.036, respectively), but no differences on day3and day7. But in the highest group, ALT and AST had a slowlydecline curve and a longer hospital stay time(P<0.05). With respect to postoperativecomplications, the overall complication rate was19.51%(8/41),30.0%(3/10) in thehighest-replication group,20.0%(3/15) in the middle-replication group, and12.50%(2/16)in the low-replication group, respectively.Conclusion: The high level of HBV-DNA has more complications, a longer hospital staytime and high levels of AST and ALT after surgery. It suggests that keeping a low level ofHBV-DNA during perioperative period would reduce the risk of surgery for patient withportal hypertension.