Synthesis, Antioxidant And Anticancer Activities Of 1,2,5-Selenadiazole Derivatives

A series of 1,2,5-selenadiazole derivatives have been synthesized, characterized and studied for their biological activities, including DNA-binding properties, in vitro antioxidant and anticancer activities. Many interesting results have been obtained, including:1. Seven 1,2,5-selenadiazole derivatives have been synthesized and characterized by ESI-MS,1H-NMR, IR, UV-Vis absorption spectroscopy and fluorescence spectroscopy.2. In vitro antioxidant activities of the synthetic 1,2,5-selenadiazole derivatives were evaluated by using two different free radical scavenging assays, namely, the ABTS assay and DPPH assay. The results showed that selenadiazole derivatives could effectivley scavenge the ABTS and DPPH free radicals in a time-and dose-dependent manner. Among the tested compounds, the compound with amino substituent group shows the strongest activty.3. The in vitro anticancer activities of the synthetic 1,2,5-selenadiazole derivatives were screened by MTT assay against various human cancer cell lines. The results show that 1,2,5-selenadiazole compounds could effectively inhibit cancer cell growth in a dose-dependent manner.4. The DNA-binding properties of these synthetic compounds have been investigated by UV-Vis and fluorescence spectrometry and viscometry. The results shows that 1,2,5-selenadiazole derivatives could bind to CT-DNA, and the trend for the DNA binding property is consistent with the in vitro anticancer activity.