Studies On Preparation And Properties Of Porous HPMC Gel Beads

The HPMC hydrogel beads were prepared by inverse suspension polymerization, in which divinylsulfone(DVS) was used as crosslinker. The amphiphilic copolymer of tripolyglycerol monostearate was used as dispersant and cyclohaxane was used as the organic phase. In addition, the porous hydrogels were prepared, in which calcium carbonate and polyethylene glycol were used as porosigen.There are three parts in this paper: The technics of inverse suspension polymerization, porous hydrogels prepared by calcium carbonate and porous hydrogels prepared by polyethylene glycol. In the first part, the factors influencing the water absorption capacities of the hydrogels such as temperature, solution concentration, the amount of crosslinker were characterized. The factors which affect the stability of the polymerization and the factors which affect the particle size were also investigated. In the part of preparing porous hydrogels, the effect of porosigen on the surface and structures of the beads, swelling velocity, swelling degree and swelling kinetics were investigated. The porous structure was made when the porosigen dosage reach the enough quantity.The swelling kinetics was well investigated. The effect of structure and aspect area on swelling behavior was well characterized. As aspect area increased, the swelling velocity was increased.The surface structures, morphology of hydrogels beads and aspect area were characterized by IR, SEM and DSC. etc.