Application Of Membrane Technology In Production Of Riboflavin By Fermentation

Riboflavin is one of the necessary B Vitamins for the organs. Now, only the Hubei GuangjiMedicine Corporation and Shanghai Desano Vitamins Corporation can manufacture riboflavin.To compete with those famous combines, such as BASF,Roche, the membrane separationmethods were used to deal with the downstream processing in the manufacture of riboflavin. Themembrane methods reduce the manufacture processes; recycle the dismissed riboflavin, reducingthe costs and achieve cleaner production. In this paper, the parameters of using inorganicmicrofiltration membrane methods to desperation, concentrate riboflavin oxide crystallizationand organic nanofiltration membrane to deal with waste water are described in detail. 1.According to compare the flux intensity and attenuation with membranes which havedifferent apertures, the best membrane dimension is 0.2μm. 2.In this paper, we emphasis on the best manipulation parameters of microfiltrationmembrane and nanofiltration membrane. In ideally conditions, the membrane flux increase withthe increasing of pressure, temperature and flow velocity. But in this experiment, because of thecharacterizes of materials and membrane, the best working parameters are as follows, thepressure is 0.2MPa, temperature is 30℃, flow velocity is 5.0m/s and the condense ratio should beless than 4.4 times. In these conditions, after watering, condensing and desperation of theriboflavin, the suitable products can be gotten. The best working parameters of nanofiltration areas follows, the pressure is 0.7~2.0MPa, the flow temperature is 30℃ ,the flow velocity is18L/min and the condense ratio should be 5.6 times. In these working conditions, after dealingwith the raw materials, we can recycle about 150 tons riboflavin per year and gain about more20,000,000 RMB per year. The CODcr of the waste water decrease from 24000mg/L to 190mg/Lnow and the BOD of waste water decrease from 8000mg/L to 30mg/L. 3.The pollution and clean of membrane are inevitable in the applications of membrane. Inthis paper the clean methods of microfiltration membrane are that clean the membrane by alkalifirstly and then using acid. After cleaning, the water filtration ratio is 98.6%, and after thecompound cleaning methods of nanofiltration membrane, the water filtration ratio is 99.1%. 4.In this paper, comparing the investments and costs of the new technics with the old, wefind that with the same investments and costs, about 19,500,000 RMB benefits can gain byrecycling riboflavin from waste water. And the investments can reward in about one year.Theyield of new technics is 92%,which is more than the old one by 12 per cent. And the cost of newtechnics is lower 13.3% than the old one.