Design And Synthesis Of Thiol C-Glycoside Derivatives And Peptide Analogues

Lectin is a kind of specific protein which can identify and combine sugar in glucolipid and glycoprotein. Lectin changes as the sugar on the membrane changes during cell growth in different stages and play an important role in cell recognition and adhesion reacction. Based on the specific identification between lectin and carbohydrate, we designed and synthesized two kinds of Thiol C-Glycoside Derivatives (glucose and galactose). By detecting the interaction between sugars and different lectins through electrochemical methods, we expect to get a testing result and refine the design of potential biological probe molecules, which may provide a new testing method for the medical field.CDC25B is a cell-cycle regulatory protein. Its encoding 20pl3 has been considered as a new oncogene. Therefore, CDC25B has become a new target for treacting malignant tumors. Overviewing CDC25B inhibitors, we found that molecules containing carboxyl and electrophilic structures exhibit good CDC25B inhibition. Targeting at the active site of CDC25B, we designed and synthesized tyrosine/phenylalanine peptide analogs and evaluated their inhibitory efficacy in vitro. The results showed that this series of compounds have rEtOAcsonable inhibition activities against CDC25B. In addition, via potential polarization experiment, impedance test and scanning electron microscope, we found that compound 41 and 44 boast of corrosion protection and hence are corrosion inhibitors.