Correlation Analysis Between Traditional Chinese Medicine Syndrome Elements And Clinical Indexes Of High Myopia Patients In Young Adults

In the understanding of high myopia with Traditional Chinese Medicine(TCM),there are some problems in clinical practice such as inconsistent classification criteria,subjective differentiation of syndrome,seriously affect the accuracy of syndrome differentiation and objectification of curative effect judgment.Syndrome element differentiation,the index is quantified,which finds a new idea for the quantitative research of TCM.。This research takes syndrome elements as the starting point to discuss the features of TCM syndrome element of high myopia patients in young adults,and to discuss the relationship between major Traditional Chinese Medicine syndrome elements and clinical indexes such as diopter(D)、axial length(AL)、subfoveal choroidal thickness(SFCT)、central foveal retinal thickness(CRT)、superficial retinal layer vascular density(SRL-VD)、superficial retinal layer skeletal density(SRL-SD)、deeper retinal layer vascular density(DRL-VD)and deeper retinal layer skeletal density(DRL-VD),expect to provide reference basis for TCM treatment and prevention of complications of high myopia patients in young adult。Objective1、To analyze the features of Traditional Chinese Medicine syndrome element of high myopia patients in young adults。2、To analyze the relationship between major Traditional Chinese Medicine syndrome elements and clinical indexes of high myopia patients in young adult,major clinical indexes include diopter(D)、axial length(AL)、subfoveal choroidal thickness(SFCT)、central foveal retinal thickness(CRT)、superficial retinal layer vascular density(SRL-VD)、superficial retinal layer skeletal density(SRL-SD)、deeper retinal layer vascular density(DRL-VD)and deeper retinal layer skeletal density(DRL-VD)。3、expect to provide reference basis for TCM treatment and prevention of complications of high myopia patients in young adult。MethodsThe information of high myopia patients in young adults was collated according to the TCM four diagnostic methods,to analyze the features of Traditional Chinese Medicine syndrome element using syndrome element differentiation,and to analyze the effect of gender and refractive diopter on syndrome element。At the same time,measured the clinical indexes diopter(D)、axial length(AL)、subfoveal choroidal thickness(SFCT)、central foveal retinal thickness(CRT)、superficial retinal layer vascular density(SRL-VD)、superficial retinal layer skeletal density(SRL-SD)、deeper retinal layer vascular density(DRL-VD)and deeper retinal layer skeletal density(DRL-VD),to compare the difference of clinical index of syndrome elements with 50%frequency of and major single Traditional Chinese Medicine syndrome elements。Results1、Distributed TCM syndrome element of high myopia patients in young adults:there were 12 disease location of TCM syndrome element:lung、heart、stomach、spleen、liver、kidney、small intestine、large intestine、gallbladder、bladder、surface and mind,the syndrome element degree was moderate;there were 14 characteristic of TCM syndrome element:fluid deficiency、blood heat、dryness、blood stasis、blood deficiency、cold、Qi stagnation、blood cold、Yin deficiency、Qi deficiency、dampness、heat、exopathic wind and Yang deficiency,the syndrome element degree was moderate and mild。2、Influence of gender on syndrome element:it had no statistical significance on frequency distribution(X2 disease location=11.451，P disease location=0.406;X2 characteristic=20.991,P characteristic=0.073),,but had statistical significance on integral(F disease location=296.394,P disease locaticn=0.000;F characteristic=148.042,P characteristic=0.000)。The male heart、spleen、liver、kidney,syndrome elements score higher than female;the female blood stasis、blood deficiency、Yin deficiency、Qi deficiency、dampness and Yang deficiency,syndrome element score higher than male。3、Influence of refractive diopter on syndrome element:it had no statistical significance on frequency distribution(X2 disease location=4.786,P disease location=0.941;X2characteristic=4.138,P characteristic=0.990),,but had statistical significance on integral(F disease location=2.185,P disease location=0.014;F characteristic=1.965,P characteristic=0.022)。In the ≥-10.00D group,Liver、kidney、dampness and blood deficiency,syndrome elements score higher than the<-10.00D group;while In the<-10.00D group Yin deficiency and Yang deficiency syndrome element score higher than the ≥-10.00D group。4、Syndrome elements with a frequence of>50%:lung(82.72%)、heart(70.37%)and stomach(66.67)of patients with disease location syndrome element;fluid deficiency(75.31%)、dryness(69.14%)、blood heat(64.20%)、blood stasis(60.49%)and blood deficiency(51.85%)of patients with characteristic syndrome。5、Differences in clinical indexes of>50%syndromes element:among the syndromes of disease location and characteristic,the differences in clinical indexes were not statistically significant(all p>0.05)。In the subsequent pair comparison among the characteristic syndromes there were statistically significant differences in AL and CRT between the blood stasis group and the blood deficiency group(p=0.031 and P=0.009)。6、The relationship between>50%single syndromes element and clinical indexes:in disease location of TCM syndrome element,lung was positively correlated with SFCT,heart was positively correlated with CRT and SRL-VD,stomach was negatively correlated with DRL-VD and positively correlated with DRL-SD。In characteristic of TCM syndrome element,fluid deficiency was negatively correlated with CRT,dryness was positively correlated with DRL-VD,blood deficiency was negatively correlated with CRT。Conclusions1、There were 12 disease location(the main was lung、heart、stomach)and 14 characteristic(the main was fluid deficiency、blood heat、dryness)of TCM syndrome element of high myopia patients in young adults,the syndrome elements degree was moderate。2、Gender and refractive diopter had no effect on frequency distribution but effect on integral of syndrome element。3、Differences in clinical indexes of>50%syndromes element:among the syndromes of disease location and characteristic,the differences in clinical indexes were not statistically significant(all p>0.05)。In the subsequent pair comparison among the characteristic syndromes there were statistically significant differences in AL and CRT between the blood stasis group and the blood deficiency group,which may indicate the different prognosis。4、A certain relationship between single syndromes element and clinical indexes may indicate the susceptibility to disease。...