Regulatory role of cytokines in the development of tumoricidal function in mononuclear phagocytes from different anatomical sites of cancer patients

The purpose of this project was to investigate the regulatory role of different cytokines on the development of tumoricidal function in macrophages from different anatomical sites of cancer patients. For this investigation, alveolar macrophages from lung cancer patients, peritoneal macrophages from ovarian cancer patients, and peripheral blood monocytes from both groups of patients were used. The capacity to express mRNA for IL-1;The results demonstrate that IL-6 plays an inhibitory role in the development of tumoricidal function in alveolar macrophages from lung cancer patients. In contrast, the inhibitory effect of IL-6 was not observed in either peritoneal macrophages from ovarian cancer patients or peripheral blood monocytes from lung and ovarian cancer patients. Neither TNF;Taken together, these studies have demonstrated that the tumoricidal functions of macrophages from different anatomical/tumor sites of cancer patients have distinct cytokine sensitivities. These results are expected to enhance the understanding of the role of macrophages from different anatomical/tumor sites of cancer patients in tumor growth or suppression. They may provide a rationale for developing immunotherapeutic approaches for human tumors according to anatomical site.