Role of YY1 in regulating human epsilon and gamma-globin gene expression

ranscription factor YY1 is a ubiquitous protein that has many functions. It has been shown to be an activator or a repressor of gene expression and can participate in developmental regulation of gene expression. Early studies in our laboratory identified several conserved YY1 binding sites near the ;This study began with the mapping of YY1 genes in the mouse and human. The mouse YY1 gene was found to be a single-copy gene, mapping to mouse Chromosome 12. No known mouse mutations were found to co-localize with YY1. In the human, there is apparently more than one YY1 gene or YY1 gene-like sequence.;To study the function of specific YY1 binding sites near the...