A syndecan-1 expressziovaltozasai es a HPV-fertohzottseg: Onallo es kolcsonhato faktorok a laphamrakok prognozisaban es progressziojaban

Syndecan-1, a transmembrane proteoglycan may exert anti-proliferative effects, but may also promote cell growth by binding various growth factors. Malignant epithelial cells often down-regulate their own syndecan-1 production, whereas they are capable of inducing an aberrant syndecan-1 expression in stromal fibroid cells. Immunohistochemical analysis performed on 40 oral leukoplakias, 51 invasive oral squamous cell cancers and 35 in situ and 56 invasive carcinomas of uterine cervix revealed one or both of the above alterations concerning syndecan-1 expression. A decrease in syndecan-1 expression compared to normal epithelium could occasionally be detected as early as in leukoplakias, representing premalignant oral lesions. Syndecan-1 expression of tumor cells was decreased or even completely lost in 45/51 oral carcinomas and in all cervical carcinomas. Furthermore, tumor-induced stromal syndecan-1 immunoreaction appeared in 19/51 oral tumors. In the case of oral cancers the probability of postoperative progression showed some dependence on the degree of decrease in tumour cell syndecan-1 levels. Based on recurrence and overall survival data, stromal syndecan-1 expression in primary oral cancers appears to be a more reliable factor of adverse prognosis.(p=0.023) We also detected the tumor-induced stromal syndecan-1 expression in the case of cancers of uterine cervix; however, the question whether the presence and extent of stromal syndecan-1 expression can be considered real risk factors of postoperative progression in these malignancies requires further clinical investigation.;Numerous lines of evidence indicate that head and neck squamous cell carcinomas associated with human papillomaviruses form a special molecular subgroup. However, HPVs' role in the pathogenesis of oral cavity cancers is still a matter of debate. Our aim was to analyze the presence of HR-HPVs DNA and E6 protein in oral cancers. Fifty-one oral carcinomas were assayed for HPV by PCR, and parallelly by E6 protein immunohistochemistry. Our results are consistent with the idea that a distinct subgroup of oral cancers are HR-HPV-associated, although not all PCR positivity means a real causative relationship between virus and malignancy. The syndecan-1 expression of the HPV 16 PCR/IHC positive tumours was higher than cancers lacking the virus, which support the idea, HPV-associated head and neck cancers form a distinct entity.