Research On The Neural Physiological Response And The Regulation Methods Of Multi-modal Physical Stimulation For Motor Learning

Motor learning is the ability to learn new movements and alter existing movements,which is closely related to many brain functions.Based on existing neurophysiological researches,motor learning can help further understanding the motor-function-related neurophysiological and pathological mechanism,it can also verify the effectiveness of new modulation methods in the application of motor learning,and it guides the design of proper modulation methods and strategies.It has important practical significance and broad application prospect in many major fields such as health care,military defense,art training and sports training.Currently,the ability of single physical stimulation to promote motor learning is limited,and training strategy lacks objective evaluation indexes.To solve these problems,studies were conducted on both neural mechanism and modulation method in this thesis.First,motor imagery/execution experiments with different physical stimulation parameters and modes were designed.Besides,the influence of physical stimulation on motor cortex activity related to motor imagery/execution is investigated.Also,to improve the neural plasticity,training strategy with optimized parameters is explored.What’s more,multimode physical stimulation method is designed,and individual clinical tests are carried out,verifying that long-duration multimode physical stimulation-induced training is effective for improving motor learning ability.Results including: 1)combining EEG and NIRS,this study reveals that,for motor cortex response of the visually-induced motor imagery task and the pure motor imagery task,there are significant differences in the contralateral primary motor cortex and sensorimotor cortex of the high mu rhythm(10-12Hz),the ipsilateral sensorimotor cortex of the low beta rhythm(14-22hz),and the contralateral parietal association cortex of the high mu and low beta rhythm,and confirms the enhancement effect of visual pathway physical stimulation on cortical response of motor imagery.2)this study proves that functional electrical stimulation(FES)combined with motor imager is more helpful in activating the motor cortex.Therefore,FES could enhance the activities of alpha rhythm at supplementary motor area,primary motor area and sensorimotor area,as well as the activities of beta rhythm at sensorimotor area.3)from the behavioral and electrophysiological aspects,this study verifies that 20 Hz transcranial alternating current stimulation(tACS)could improve motor learning ability by modulating neural activity related to motor.4)this study designs stroke rehabilitation training system based on training-brain computer interface and multimode physical stimulation method.The results of routine test and clinical test of typical cases demonstrates the effectiveness of the proposed training system and the proposed stimulation method.In summary,this thesis carries out innovative and applied research work on the neurophysiological response of motor learning and the multi-mode physical modulation method.Research results provide valuable exploration basis and application enlightenment for the theoretical exploration and practical application of the neural plasticity mechanism for motor learning,provide new ideas and methods for the establishment of multi-mode physical stimulation-induced training model,and provide theoretical basis for the clinical application of the new physical stimulation-fusion model.