Clinical Research On The Relation Between Metabolic Syndrome And Excessive Daytime Sleepiness Or Simple Snoring

Objective:Excessive daytime sleepiness(EDS)and snoring are typical symptoms of obstructive sleep apnea hypopnea syndrome(OSAHS).This cross-sectional study aimed to assess the relationship between metabolic syndrome(MetS)and EDS or simple snoring,and determine whether EDS or snoring could be used as simple clinical tools for evaluating the risk of MetS among OSAHS patients.Methods:First,we included 2241 male subjects and divided them into different groups according to Epworth sleepiness scale(ESS)score.The metabolic parameters were compared between EDS group and non-sleepy group.The relationship between ESS score and metabolic score was analyzed by linear regression after adjusting for other confounders,including age,obesity,sleep parameters,smoking status and alcohol consumption.We further calculated odds ratios(ORs)for MetS according to sleepiness status by means of logistic regression.Second,we included 387 simple snorers(AHI<5)and 139 controls.The differences of metabolic parameters between two groups were compared.Linear regression was used to analyze the relation between snoring intensity score and metabolic score,and logistic regression was used to evaluate whether simple snoring could increase the risk of MetS after controlling for age,sex,obesity,smoking status and alcohol consumption.Results:The results showed that EDS patients presented more severe metabolic disorders and higher prevalence of MetS.There was a significant linear correlation between ESS score and metabolic score.EDS could significantly increase the risk of MetS(OR=1.297,95%Cl:1.070-1.572),and such relation was only significant in hypertriglyceridemia(OR=1.208,95%CI:1.003-1.455)and hyperglycemia(OR=1.286,95%Cl:1.046-1.582).At the same time,simple snorers showed more severe metabolic disorders and higher prevalence of MetS than controls.Snoring intensity score was linear correlated to metabolic score significantly.Simple snoring could significantly increase the risk of MetS among female(OR=2.307,95%Cl:1.039-5.122),and the effect of simple snoring was only significant in general hypertension(OR=1.691,95%CI:1.022-2.800)and female abdominal obesity(OR=2.517,95%CI:1.210-5.236).Conclusions:EDS was independently associated with elevated risk of MetS,and such relation was more obvious in hypertriglyceridemia and hyperglycemia.After excluding the effects of apnea,simple snoring could significantly increase the risk of MetS among female.The effect of simple snoring was more obvious in general hypertension and female abdominal obesity.Our findings suggested that the evaluation of EDS and snoring could be used to screen for high-risk group of MetS conveniently.