| ObjectiveChronic fatigue syndrome(CFS)is a kind of disease with unexplained chronic fatigue as the main symptom.Since the etiology and pathogenesis of chronic fatigue syndrome have not been clearly defined,no targeted treatment measures for the disease have been found,and symptomatic treatment is the main treatment in clinical practice.There is no consensus on the etiology and mechanism of CFS in Chinese medicine.Therefore,it is of great practical significance to explore the pathogenesis of CFS.The theory of "five-viscera correlation" established by professor deng tietao,a Chinese medicine master,has been widely used in the study of disease pathogenesis.Therefore,we plan to explore the Chinese medicine disease mechanism of CFS under the guidance of the theory of five-viscera correlation,and study the zang-fu-organs correlation mechanism of CFS,so as to provide theoretical support for the prevention and treatment of CFS in Chinese medicine.Methods1.By means of literature retrieval,the five-viscera correlation clinical syndrome investigation form of chronic fatigue syndrome was developed,which contains more than 200 syndromes related to chronic fatigue syndrome,as well as the necessary items of disease inducers,medical history,basic data of patients and so on.2.According to the diagnostic criteria,inclusion criteria and exclusion criteria of CFS,a total of 280 cases were included,and the patients were instructed to fill in the five-viscera correlation clinical syndrome questionnaire.3.EpiData software was applied to input the survey data into the computer and eventually exported the Stata format database.4.Stata software was used for data statistical analysis:(1)Make statistical analysis of the patient’ s disease causes,medical history and basic data;(2)Spearman correlation analysis was adopted to analyze the five viscera syndromes to explore the internal correlation of the five viscera system;(3)Cluster analysis was used to analyze the clinical syndromes of patients to classify the patients;(4)Factor analysis was used to analyze the clinical syndromes of the patients to clarify Chinese medicine syndromes.5.According to the statistical results,the clinical syndrome types of chronic fatigue syndrome were analyzed,and the disease mechanism was discussed.On this basis,the methods of subcomponent type and prevention and treatment of Chinese medicine were discussed.Results1.Statistical results of disease causes,medical history and basic data:A total of 280 patients were included in this study,including 97 males and 183 females,with a male to female ratio of 1:1.89.The patients ranged in age from 20 to 55 years old,more than 70%of the patients were under 40 years old,the course of disease was 39.10±54.30 months,the duration of education was 15.10±3.91 years,and more than 50%of the patients were university students,enterprises and employees.Of the 14 possible causes,staying up late and not exercising were the most frequent.Of the 15 possible histories investigated,rhinitis/sinusitis was reported at the highest rate.2.According to the frequency statistics,the liver and gallbladder system and the spleen and stomach system have the highest frequency,followed by the heart and small intestine system and the kidney and bladder system,while the lung and large intestine system have the lowest frequency.In addition to the hepatobiliary system and the splenogastric system,the syndrome differences between the two systems were statistically significant,that is,the hepatobiliary(splenogastric)system syndrome>heart and small intestine system syndrome>kidney and bladder system syndrome>lung and large intestine system syndrome.Spearman correlation analysis showed that the hepatobiliary system was strongly correlated with the cardio-intestinal system,the splenogastric system was strongly correlated with the hepatobiliary system,the renal bladder system was moderately correlated with the splenogastric system and the hepatobiliary system,and the pulmonary large intestine system was weakly correlated with other visceral systems.The correlation between the above zang-fu systems was positive and statistically significant.3.Cluster analysis results:280 CFS patients were grouped into three categories,category 1 contained 121 patients,category 2 contained 123 patients,and category 3 contained 36 patients.There were no statistically significant differences in gender,age,age of onset,body mass index and other aspects among the three groups of patients.Patients in the second group had a longer duration of illness and a shorter duration of education than those in the other two groups.The difference in the frequency of the three types of patients was statistically significant,and the frequency of the first,second and third types of patients showed an increasing trend.4.Internal correlation analysis results of five viscera systemsSpearman correlation analysis was adopted to analyze the data of five-viscera system syndromes of each type of patients:(1)There is a certain correlation between the five viscera systems of each type of patients;(2)In the first group of patients,the cardio-intestinal system and the hepatobiliary system are the main syndromes.Within the five viscera system,the cardio-intestinal system has a certain degree of independence and is associated with the hepatobiliary system.The hepatobiliary system has a strong correlation with the renal bladder system and the splenogastric system;(3)The basic syndromes of category 2 patients are the syndromes of the spleen and stomach system and the hepatobiliary system.Within the five viscera system,the spleen and stomach system has a certain degree of independence and is associated with the renal bladder system and the hepatobiliary system,while the hepatobiliary system has a strong correlation with the heart and small intestine system;(4)The basic syndromes of the third group of patients are the syndromes of the hepatobiliary system,the spleen and stomach system and the heart and small intestine system.Within the five viscera system,the heart and small intestine system has a strong correlation with the hepatobiliary system,the spleen and stomach system has a certain degree of independence,and the hepatobiliary system has a strong correlation with the kidney and bladder system.(5)The correlation between the zang-fu systems mentioned above is positive and statistically significant.5.Factor analysis resultsBased on factor analysis and basic knowledge of Chinese medicine,the basic pathogenesis of chronic fatigue syndrome is deficiency of qi and blood,which can be divided into 10 syndrome types,including blood deficiency of blood,spleen and liver,liver stagnation and spleen deficiency,spleen Yang deficiency,heart and kidney incompatibility,spleen and kidney deficiency,liver and kidney Yin deficiency,spleen and lung qi deficiency and qi stagnation and blood stasis.Among them,patients in the first group were mainly deficient in blood work,patients in the second group were mainly deficient in temperament,patients in the third group were mainly deficient in heart,liver and blood,and patients in the third group had the highest syndrome frequency,obvious cold and heat,and complicated condition.ConclusionThere is a certain correlation between chronic fatigue syndrome and the five viscera system of Chinese medicine.This disease is a multi-system related chronic weakness disease involving the five viscera system of Chinese medicine,and its basic pathogenesis is "deficiency of qi and blood".Chronic fatigue syndrome is closely related to the dysfunction of the heart,liver,spleen,kidney and other four viscera,but is weakly related to the lung.The symptoms of hepatobiliary system and spleen and stomach system were the most.Within the five viscera system,the hepatobiliary system has a strong correlation with the cardiointestinal system,and the splenogastric system has a strong correlation with the renal bladder system and the hepatobiliary system.Long-term excessive mental or(and)physical exertion,stress,irregular diet,and circadian rhythm disorder may be the main causes of the disease.Fatigue was the most frequently reported symptom,and cognitive and sleep disorders were the most frequently reported complications in the diagnostic criteria.On the basis of investigation and research,we proposed a preliminary subgroup method for patients with chronic fatigue syndrome.In the aspect of prevention and treatment,we put forward the prevention strategy under the guidance of the theory of Chinese medicine health preservation and the comprehensive intervention measures of Chinese medicine based on "fatigue three needles". |
PDF Full Text Request