| Cerebral infarction is a disease of ischemic stroke which is often seen in department of neurology,and it is one of majority disease which can cause severe harmfulness to people’s health.Progressive cerebral infarction(PCI)is charcteristy by rapid development,more disability and high fatality rate.lt is difficult to forecast and difficult to handle in treatment,so it is easy to cause tensions between doctors and patients.Therefore,it is a important task to explore treatment method and improve prognosis of Progressive cerebral infarction.ObjectiveThis study is to investigate effection of dl-3-n-Butyphthalide injection on efficasy observation,CD34+cells,high sensitive C reactive protein(hs-CRP),mean velocity and pulse index in patients with Progressive Cerebral Infarction.MethodBased on the National institute of health strokes scale(NIHSS),82 cases of progressive cerebral infarction were collected from the Second People’s Hospital,JiangSu Huaian.82 patients with PCI were randomly devided into treatment group and control group.Both the two groups were given the treatment to adjust blood pressure,control blood glucose,promoting cerebralvascular circulation,anty platelet aggregation and applicate stains drugs.Dl-3-n-Butyphthalide injection was administrated to the patients in the treatment group for two weeks in addition to basic therapy,twice a day.All the patients have been evaluated by NIHSS in the time of the second weeks after initiating the therapy.Modified Rankin Scale(MRS)was assessed on the day which PCI began and the time which the treatment was ended for 90 days.Vm and PI was evaluated with transcranial doppler(TCD)to explore cerebral blood flow and vascular resistance on the day which PCI occurred and the day which the dl-3-n-Butyphthalide injection therapy was over.The level of blood CD34+cells were detected by flow cytometry,observe the NBT to improve the situation of intracranial angiogenesis and collateral circulation.hs-CRP was checked with immunoturbidimetry method to tested whether NBT can control inflammation which PCI induced.Results1.Before progressing,NIHSS was 6.78±3.22 in the treatment group,and NIHSS of the control group was 7.07±3.93,The NIHSS between the two groups had no stastistically significant difference.After progressing,NIHSS of the treatment was 15.53±4.47,and the control group was 15.79±4.21.The NIHSS difference between the two groups was not stastistically significant(P>0.05)2.After treating with NBT,NIHSS of the treatment group was 11.27±2.63 in one week,and 7.02±2.98 in two weeks.Meanwhile,NIHSS of the control group was 13.35±2.65 in one week,and 10.47±2.53 in two weeks.The NIHSS change in the treatment group before and after treating is obvious,and the difference is stastistically significant(P<0.05).Two weeks later with treating,NIHSS between the two groups were stastistically significant(P<0.05).3.After two weeks treating,of all the 40 PCI patients in control group,2 ptients were cured,7 significant progress,19 the progress,8 patients ineffective,4 deterioration and 0 death.the effective rate was 22.50%.In the total 42 PCI patients in treatment group,6 patients were cured,22 significant progress,10 the progress,3 patients ineffective,1 deterioration and 0 death.the effective rate was 66.67%.The difference between the two groups was significant(P<0.05).4.On the day of PCI occurred,MRS between the twogroups,u =0.84,P>0.05,there was no difference between the group.On the 90th day after treating with NBT,u=18.4,P<0.05,P<0.05the difference is significant(P<0.05).5.When PCI was occurred,Vm of MCA in treatment group was 44.68±7.43,and it in control group was 45.02±7.33.PI of MCA in treatment group was 0.83±0.11,and it in control group was 0.82±0.12.the difference of Vm and PI were no significant between the two groups,(P>0.05).treated for two weeks later,treatment group Vm was 53.56±7.62,and the control was 47.38±7.31.PI in treatment group was 0.68±0.13,and it in control group was 0.76±0.13.there was significant difference of Vm and PI between the two groups(P<0.05).6.On the day of PCI occurred,Vm of PCA in treatment group was 44.68±7.43;and it in control group was 45.02±7.33.PI of PCA in treatment group was 0.83±0.11,and it in control group was 0.82±0.12.the difference of Vm and PI were no significant between the two groups,(P>0.05).treated for two weeks later,treatment group Vm was 53.56±7.62,and the control was 47.38±7.31.PI in treatment group was 0.68±0.11,and it in control group was 0.76±0.13.there was significant difference of Vm and PI between the two groups(P<0.05).7.Before treating,the level of hs-CRP was 13.56±3.88mg/L in the treatment group,and,hs-CRP in the control group was13.49±3.92mg/L.The hs-CRP between the two groups had no stastistically significant difference(P>0.05),After two weeks treating,hs-CRP was 8.47±2.72mg/L in the treatment group,and,hs-CRP in the control group was10.53±2.69mg/L,The difference between the two groups is significant(P<0.05).8.Before treating,the blood CD34+cells were 0.035±0.06%in the treatment group,and it in the control were 0.036±0.08%,there was no stastistically significance between the two groups(P>0.05),.After treating,the treatment group blood CD34+cells were 0.074±0.08%,and the control were 0.045±0.09%,the diffrence is statistically significant(P<0.05).Conclusion:After the patients with PCI were treated with the dl-3-n-Butyphthalide injection(NBT),it can relive the degree of the patients,neurological impairment,improve the short-term efficency.NBT can increase the score of MRS and better long-term effect of treating.NBT can decrease the serum hs-CRP concentration in patients with PCI and has anti-inflammatory effect.NBT can arise the level of CD34+ cell in patients,promote angiogenesis and collateral circulation.NBT can improve the cerebral blood flow and increase blood supply in ischemic area. |
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