The Academic Thought And Clinical Inheritance Of Professor Yu Junsheng In Treating Chronic Renal Failure With Harmonizing Therapy

Objective : Using Chinese medicine inheritance research methods, summarizing proffessor Yu Junsheng’s clinical experience, medication characteristics and prescription composition from the theoretical discussion, data mining and clinical research.Inherit and develop tutor’s academic thoughts and clinical experience.Method:1. Through weekly learning from teachers, collecting prescriptions of the tutor, writing teacher’s notes and learning experience, listening to the tutor’s dictation and so on, and thoroughly arranging professor Yu Junsheng’s academic papers which can reflect his academic thought and clinical experience, accessing to the relevant literature, tracing the tutor’s academic origin, looking for a theoretical basis, summarizing tutor’s academic thoughts and clinical experience.2. Collecting professor Yu Junsheng’s outpatient and inpatient medical records in treating chronic renal failure(CRF);Optimizing 175 prescriptions according to the project design, using TCM inheritance auxiliary system(v2.5), systematically analyzing professor Yu Junsheng’s treatment and prescription rules in treating CRF, deeply digging the medication rules, and systematically summarizing professor Yu Junsheng’s medical characteristics and experience in treating CRF.3. Based on professor Yu Junsheng’s “kidney collateral stasis pathogenesis”of CRF, and the theory of calcium and phosphorus metabolism disorder complication related to “spleen deficiency and generating wind”, forme Heluoningfeng Granule by harmonizing collaterals and inducing dampness, purging turbid pathogenic factors, removing toxic substances, and elevating earth to tranquilize wind,valuate Heluoningfeng Granule’s effect on the CRF with the disorders of calcium and phosphorus metabolism through clinical research.Results:1. Academic ideological origins: Professor Yu Junsheng is the student of Mr. Li keshao, professor of Qilu typhoid, and is the representative heritage of Qilu shanghan school, good use of syndrome differentiation of the Six Meridians Theory for the treatment of renal diseases, creatively proposed new theories and methods such as “CRF related to shaoyang disease”, “CRF treated with harmonizing therapy”, and created three settlement methods in the treatment of CRF, namely, reconciling shaoyang, purging turbid pathogenic factors and removing toxic substance; regulating ascending and descending, harmonizing middle energizer and removing toxic substance, harmonizing collaterals and inducing dampness, purging turbid pathogenic factors and removing toxic substances. Attention to special disease with special prescription and special medicine, achieved remarkable curative effect in CRF treatment and accumulated rich clinical experience.2. It overviewed professor Yu Junsheng’s academic thought on the treatment of CRF with harmonizing therapy, theoretically and clinically explains the CRF harmonizing theory, introduced his clinical experience on the use of treatment of CRF and use of medicine in the treatment of CRF, and analyzed the typical medical cases with the clinical examples.3. Based on TCM inheritance auxiliary system, analyzed professor Yu Junsheng’s treatment of CRF medical record radix astragali, radix scutellariae, leech, epimedium, radix codonopsis, sage, bupleurum root, amomum villosum. Found the combination pattern of CRF drugs by use of the association rules and the pattern of CRF based on entropy method.4. Clinical study indicated that Heluoningfeng Granule could improve the clinical symptoms of CRF patients with calcium and phosphorus metabolism disorder, correct calcium and phosphorus metabolism, improve anemia and nutritional status and renal function, and delay the progress of renal failure.Conclusions:1.Precise, professor Yu Junsheng has creatively put forward the theories that “CRF related to shaoyang disease” and “CRF treated with harmonizing therapy”, summerized three methods of CRF harmonizing therapy which are reconciling shaoyang, purging turbid pathogenic factors and removing toxic substance; regulating ascending and descending, harmonizing middle energizer and removing toxic substance, harmonizing collaterals and inducing dampness, purging turbid pathogenic factors and removing toxic substances. Base on the TCM inheritance auxiliary system, analyse professor Yu Junsheng’s clinical experience in treating CRF, summerize the prescription characteristics with harmonizing therapy: first,reconciling shaoyang and harmonizing collaterals, inducing dampness, purging turbid pathogenic factors and removing toxic substances are the base treatment; second, syndrome differentiation, using replenish and removing at the same time which are also called both incidental and fundamental aspects treatment; third, combination pair drugs, pay attention to compatibility;fourth, gambling the characteristic of different prescriptions and make combination ingenious prescriptions based on the mechanism of the disease.2. Heluoningfeng Granule which is based on professor Yu Junsheng harmonizing therapy theory, can effectively improve patients’ clinical symptoms in CRF with calcium and phosphorus metabolism disorder, correct calcium and phosphorus metabolism disorder, improve anemia and nutritional status, improve renal function, delay the progress of renal failure. Prompt the theory based on professor Yu Junsheng’s CRF “kidney collateral stasis” and calcium and phosphorus metabolism disorder complication with “spleen deficiency generating wind”, from harmonizing collaterals, inducing dampness, purging turbid pathogenic factors removing toxic substances, and elevating earth to tranquilize wind in the treatment of chronic renal failure with calcium phosphorus metabolic disorder complication have curative effect affirmation, worthy of further research and development.