Tomography And Prognosis Of Breast Ultrasound And Pathology Control Study Light Scattering

ObjectiveTo probe the correlation between the ultrasound-guided diffused optical tomography(DOT) of breast cancer and prognosis.Materials and methods195patients (207lesions) from October2007to February2010with primary breast cancer, verified by pathology, evaluated with axillary lymph nodes, treated systematicly, with detailed imaging examination data and follow-up, were enrolled in the research. Every patients took routine preoperative ultrasonography and were recorded with all ultrasound characters. Then Ultrasound localization of light scattering tomography was used to measure the total hemoglobin concentration within lesions and generated the optical absorption map.We checked all patients’medical records and clinic medical records and recorded their clinical characters, therapy projects and the results of follow-up. Then we probe the correlation between the ultrasound-guided diffused optical tomography(DOT) of breast cancer and prognosis.Results1. The THC of breast cancer and size of lesion were closely related, The THC of lesions lager than2cm was obviously higher than those smaller than2cm(P=0.000); The THC of breast cancer was closely related with the pathology type (P=0.041), The THC of non-special type of invasive breast cancer was obviously higher than that of special type of invasive breast cancer;The THC of breast cancer was closely related with the pathology TNM stage;The THC of I stage was obviously lower than that of II and III stage(P=0.002,0.001, respectively), there was no correlation between the THC of II and III stage(P=0.369).2. The THC of breast cancer was closely related with the prognosis, and the THC of patients with recurrences or metastasis after operation was obviously higher than those without recurrences or metastasis(P=0.023). 3. The THC of breast cancer was negatively correlated with the time of recurrences or metastasis, but there was no statistical significance(r=-0.254, P=0.241).4. There was no statistical significance between THC and metastatic locations after operation(P=0.139).Conclusion1. There was correlation between the THC of breast caner and the size, pathology type, pTNM stage and recurrences or metastasis after operation.2. The THC of breast cancer was negatively correlated with the time of recurrences or metastasis Objective1. To analyse the pathology mechanism of the total hemoglobin concentration of the metastastic and non-metastasic groups.2. To analyze correlation of the THC and HIF-1α、OPN、VEGF、MVD and VM.Materials and methodsTo follow-up the195patients with primary breast cancer diagnosed from October2007to February2010, we found23patients to relapse or metastasize after operation. All these cases were matched with the non-metastastic cases according to the proportion of1:2, and there were69cases. We carried out immumohistochemical staining of HIF-1a, OPN, VEGF, CD34and double staining of CD34and PAS, then we graded all the section stained and analyzed the correlation of the angiogenesis factor and THC.Results1.THC of the metastastic group was closely related with HIF-1α and THC of the non-metastastic group was not related with HIF-1α.2.There was no relation between THC and VEGF. OPN.3. THC was rectilinearly correlated with MVD and MVD+VM. VM contributed little to the blood supply of the breast cancer.Conclusion1. THC of the metastastic group was closely related with HIF-1α and THC of the non-metastastic group was not related with HIF-1α. THC of both group was not related with VEGF and OPN.2. THC was rectilinearly correlated with MVD and MVD+VM. VM contributed little to the blood supply of the breast cancer.