Study Of Large-scale Epidemiology Survey On The Scene And Analysis Of Risk Factors Of Tuberculosis In Zheiiang Province

ObjectiveTo realize the epidemiology situation of tuberculosis (TB) through chest X-ray in major infectious disease demonstration area of Zhejiang Province, and to investigate the influencing factors on TB for prevention and cure of TB.Methods(1)From Mar.2011to Dec.2012, Chest X-ray and interrogation of suspected TB symptoms were conducted among aged15and above the permanent population by stratified clustered-random sampling in different stages in the eight TB demonstration area of Zhejiang Province.(2)714sputum smear positive TB patients and1635controls were randomly selected from the population under study and each case was matched by region, age and sex using a frequency matching method.(3) The chi-square was applied for the comparison of prevalence by SPSS18.0statistical analysis. Single-variable and multiple non-conditional logistic regression modeling were applied for data analysis of risk factors, and odds ratios (ORs) and their corresponding95%confidence intervals (CIs) were estimated.Results(1) A total of355232residents were examined, including male152839, female202393, the male to female ratio of1:1.16. The standardized prevalence of active, smesr positive and bacteriological positive pulmonary TB were181/100000,36/100000and70/100000.(2) The standardized male prevalence of active, smesr positive and bacteriological positive pulmonary TB were314/100000,64/100000and108/100000. The standardized female prevalence of active, smesr positive and bacteriological positive pulmonary TB were125/100000,26/100000and52/100000.(3) There were no statistical difference in the standardized prevalence of active pulmonary TB between island area (257/100000) and inland areas (204/100000). The standardized prevalence of active pulmonary TB in low GDP region (328/100000) was higher than high GDP region (163/100000).(4)732cases of active pulmonary TB,151cases of smesr positive pulmonary TB and271cases of bacteriological positive pulmonary TB were diagnosed.(5) A total of480male cases and252female cases were diagnosed. Elderly people aged60and above in369cases, accounting for50.41%. Engaged in farming and fishing person443cases, accounting for60.52%. Primary and culture under the socioeconomic status of397cases, accounting for54.24%.(6) Results from multiple logistic regression showed that the risk factors of TB would include the following items: history of having had TB (OR=124.040,95%CI:47.573～314.353), history of exposure to TB (OR=8.856,95%CI:4.917～21.064), being immigrants (OR=2.801,95%CI:2.424～3.793) and history of diabetes (OR=2.581,95%CI:1.276～3.559), while having had high degree of education as the protective factor of TB (OR=0.423,95%CI:0.316～0.729).Conclusion(1) Initially found out TB prevalence and characteristics of patients with TB in the different geological features and different economic development levels in zhejiang province, and fixed the study population, distinguished infected and uninfected group, provided baseline data for the second round and the third round of TB screening dynamically, to carry out the changes of TB new infections and the fatality rate. (2) Control programs targeting those ever having TB patients and contacts to TB patients as well as immigrants should be strengthened.