Research On The Diagnostic Standardization Of Liver-kidney Yin Deficiency Syndrome Of Essential Hypertension

Objective：TCM syndrome of hypertension is the important basic work of the NewCentury excellent Talent of Education Ministry support program (No.NECT-07-0522). Toestablish the macroscopic quantitative diagnostic standard of liver-kidney yin deficiencysyndrome of essential hypertension and explore a new method of standardization of TCMsyndrome differentiation.Methods： Control study of modern literature and clinical retrospective study ondistribution rule of TCM syndromes of essential hypertension were respectively carriedfirst. The macroscopic diagnostic scale of liver-kidney yin deficiency of essentialhypertension was constituted according to literature research, clinical epidemiologicalinvestigation and expert consultation.Then，the re1iability, validity and responsiveness ofthe scale were evaluated. The macroscopic quantitative diagnostic model and standard ofliver-kidney yin deficiency of essential hypertension were established by determining itemweights according to epidemiological investigation. Clinical diagnostic experiments wereperformed on the standard finally.Results： The diagnostic scale of liver-kidney yin deficiency of essentialhypertension was compiled and proved to have good re1iability, validity andresponsiveness. The quantitative diagnostic standard of liver-kidney yin deficiency ofessential hypertension was established, whose lowest critical value was197. Clinicaldiagnostic experiment showed that it had high sensitivity，specificity，accuracy andpositive likelihood ratio.Conclusion： The diagnostic scale of liver-kidney yin deficiency of essentialhypertension established through literature research，clinical epidemiological investigation, scale compilation，statistical analysis and clinical verification has good feasibility, accuracyand clinical practical value. The results of this research will offer standardized scale forfurther research of liver-kidney yin deficiency of essential hypertension, and methods forstandardization study on other syndromes.