The Correlations Between CDK2Expression And Patients’Clinicopathological Factors And Prognosis In Gastric Cancer And The Explortory Use Of NRS-2002to Screen The Preoperative Nutrition-risk In Patients With Gastric Cancer

Objective:To evaluate correlations between CDK2expression and patients’ clinicopathological factors and prognosis in gastric cancer.Methods:A total of67patients with gastric cancer underwent surgical resection from Jun2002to Jan2003were included. Expression of CDK2in tumor and para-tumor tissues was determined by immunohistochemistry. The relationship between CDK2expression and clinicopathological and prognostic variables were evaluated.Results:The expression ratios of CDK2in tumor and para-tumor tissues were77.6%and58.2%,statistical difference in them, P=0.026. The expression of CDK2in tumor tissues and para-tumor tissues has no ralationship with clinicopathological characteristic. Univariate analysis showed that patients with negative CDK2expression in tumor tissues had no significantly prolonged overall and tumor-free survival, compared with those with positive expression. TNM stage was correlated with patient prognosis, patients of an early stage had a significantly prolonged overall and tumor-free survival, compared with those of a later stage.Conclusions:Our data demonstrated that the expression of CDK2in tumor tissues is higher than para-tumor tissues. The finding indicated that CDK2might be involved in tumorigenesis of gastric cancer. Second, CDK2was not correlated with clinicopathological variables and patient prognosis. Finally, TNM stage was important for patient prognosis. Objective:The aim of this study was to evaluate the rate of nutrition risk in patients with gastric cancer by NRS-2002, to assess the correlations between nutrition risk and applications of nutrition support and health economical indexes.Methods:In this prospective study, patients in general surgery department were included from Oct2009to Apr2010. Patients received nutrition risk screening2002at the admission. Data aslo was recorded on applications of nutrition support and health economical indexes.Results:The average rate of nutrition risk in gastric cancer was62.8%, including high risk18.8%, low risk43.9%. The rate in elderly patients was86.0%. The drug expenses of elderly patients was different to not elderly, P=0.016. The hospitalized time and medical expenses were different between patients with and without nutrition risk, P<0.05, and there existed a difference of medical costs between high risk patients and lower risk, P<0.05. Compared with those without preoperation nutrition support, hospitalized time and medical expenses at nutrition risk showed a difference in patients received nutrition support, especially for elderly ones, P<0.05.Conclutions:Patients with gastric cancer, especially elderly ones, had a high rate of nutrition risk. Those with nutrition risk had higher hospitalized time and medical expenses especially high risk patients. For patients, especially elderly and high risk ones with nutrition risk, the preoperative nutritional support could reduce the time and the expenses.