Core Needle Biopsy Versus Fine Needle Aspiration Biopsy In The Axillary Lymph Nodes Of Invasive Breast Cancer: Comparison Of Diagnostic Value

Objectives:Breast cancer is one of malignant tumors and a leading cause of death of malignant tumor among women. Ultrasound is an imageological diagnosis mean commonly used in screening or diagnozing breast diseases. The diagnostic techniques are constantly improved and enhanced. Ultrasound-guided interventions have increased the precise detection rate of axillary lymph nodes metastasis. However, ultrasonic diagnosis may be limited by doctor’s subjective factors and then to affect the diagnostic effects. Due to extremely low sensitivity and specificity,the axillary lymph node staging cannot be adequately and accurately carried out prior to breast cancer surgery. Pathological results is the most accurate basis to determine whether the tumor is malignant.Pathological examination technology continues to develop. Before sentinel lymph node biopsy and minimally invasive biopsy technique have been applied to clinical practice, physicians usually choose surgical biopsy and frozen section pathology to diagnose breast cancer underwent modified radical mastectomy, which will give patients a huge body pain. With the improvement of the quality of life of women, minimally invasive biopsy technology came into being. For primary breast cancer.,Fine needle puncture and hollow core needle puncture isthe most widely used minimally invasive breast biopsy technique.Its main features are high accuracy, high speed, small wound, less complications, low cost, so it is widely welcomed by clinicians and quickly spread.Both ultrasound-guided fine needle aspiration biopsy (FNAB) and core needle biopsy (CNB) for axillary lymph nodes can enhance the specificity. This study is palnned to investigate the diagnostic value of ultrasound-guided FNAB and CNB for axillary lymph nodes in invasive breast cancer. Meanwhile, it has analyzed whether preoperative CNB and FNAB axillary lymph nodes samples can reflect the ER, PR, epidermal growth factor receptor-2 (Her-2) metastasis,6 in CNB and 14 in FNAB. The difference between methods was significant (P<0.05).In micrometastatic armpits, only one was performed above-mentioned axillary lymph nodes biopsy. The results showed axillary lymph nodes metastasis was negative using two types of biopsy technology. If the micrometastasis was explained as negativemetastasis by statistcial anlaysis again, the sensitivity of FNAB and CNB would be increased slightly,74% and 90% respectively. But the difference between methods was still significant (P<0.05).After CNB was performed to axillary lymph nodes, the ER, PR and Her-2 were 93.6%、91.5%、97.9%, respectively as same as postoperative primary tumor test results. After FNAB was performed to axillary lymph nodes, ER, PR and Her-2 were 97.9%、95.7%、97.9%, respectively as same as postoperative primary tumor test results.Conclusion:When axillary lymph nodes were carried out accurately preoperative staging in patient with newly diagnostic breast cancer, CNB is more sensitive than FNAB. It is advocated as a frontline biopsy for axillary lymph nodes of breast cancer thereby reducing or replacing unnecessary sentinel lymph node biopsy and directing further treatment. It has very high clinical values. After CNB giving to axillary lymph nodes, ER, PR and Her-2 were well in accordance with postoperative primary tumor test results (p>0.05), as well as FNAB.