Myocardial Protective Effect Of Danhong Injection Evaluated By Velocity Vector Imaging In Patients With Unstable Angina Pectoris After Percutaneous Coronary Intervention

Objective To investigate the myocardial protective effect and related mechanism ofperi-procedural Danhong injection therapy for patients underwent percutaneouscoronary intervention for unstable angina pectoris.Methods120patients were randomized into Danhong group (DG, n=60) or controlgroup (CG, n=60). Patients in CG were treated with regular medication therapyaccording to guidelines plus NS (250ml, qd) as placebo while patients in DG weretreated with regular therapy plus Danhong injection before and after PCI. During PCIprocedure,40ml Danhong injection were administrated via venous as aggressivemethod. Serum levels of CK, CK-MB, cTnT, hs-CRP, IL-6were tested before,immediately and24hs after PCI. Serum levels of SOD, MDA, sICAM-1, and vWFwere tested before and24hs after PCI. Flow-mediated dilation (FMD) VVI andregular echocardiography was performed before and24hs after PCI. Post-PCI TMPGgrade and no reflow phenomenon was assessed. Major cardiac adverse eventsincluding angina, revascularization, myocardial infarction, heart failure and cardiacdeath were recorded within3months follow-up.Results⑴After treatment with Danhong injection, serum level of CK-MB and cTnTin CG increased and was higher than DG (25.12±11.91U/L vs18.19±10.23U/L,0.132±0.011ng/ml vs0.079±0.007ng/ml, P＜0.05).⑵After treatment with Danhong injection, serum level of SOD in DG increased(88.31±6.74vs83.68±6.02, P＜0.05) and was higher than CG（88.31±6.74vs80.27±5.18，P＜0.01). Serum levels of MDA in DG decreased(4.72±1.01vs5.47±1.19,P＜0.05) and lower than that in CG (4.72±1.01vs6.73±1.59，P＜0.01). ⑶Serum levels of vWF (139.3±31.8%vs155.8±33.7%, P＜0.05）and sICAM-1(231.9±33.4ug/L vs250.8±38.5ug/L,P＜0.05) in DG decreased and lower than thosein CG (172.9±40.6%vs139.3±31.8%,278.4±44.5ug/L vs231.9±33.4ug/L,P＜0.05)respectively.⑷Serum levels of hsCRP and IL-6increased (1.89±2.73vs0.90±3.25,6.32±5.30vs4.85±3.19,P＜0.05, respectively) in DG after PCI and lower than those inCG (1.89±2.73vs3.08±3.23,6.32±5.30vs9.37±3.14, P＜0.05, respectively).⑸VVI revealed that ventricular wall movement in DG24hs after PCI improvedcompared with CG: Strain (26.01±7.94vs23.25±6.68,20.91±7.55vs18.79±8.45,18.10±7.31vs16.89±6.05,21.16±6.42vs18.37±6.54, P<0.05)and strain rate(1.93±0.79vs1.69±0.63,1.86±0.72vs1.63±0.68,1.51±0.80vs1.25±0.54,1.50±0.45vs1.33±0.32,P<0.05)of interventricular septum apex, anterior apex, inferior basement,inferior mid segment were better in DG than CG.⑹After PCI, FMD in DG decreased (7.1±3.2%vs9.2±3.6%, P＜0.05) and higherthan that in CG (7.1±3.2%vs5.5±2.5%, P＜0.05).⑺Three months follow-up showed that incidence of angina and heart failure in DGwere significantly lower than those in CG and there was no difference in myocardialinfarction and cardiac death between these two groups.Conclusion Peri-procedural Danhong injection therapy could ameliorate myocardialinjury and improve segmental systolic functionand prognosis through inhibition ofinflammation, oxidative stress and improvement of endothelial dysfunction.