Correlation Between Glucose Transplanter-1, Prognosis And ¹⁸F-Fluorodeoxyglucose Uptake In Pancreatic Cancer

Objective1. To investigate the relationship among clinical indexes, pathological characteristics and fluorodeoxyglucose uptake in pancreatic cancer.2. To describe the characteristics of glucose transplanter-1 expression,,to study the correlation between glucose transplanter-1 and flurodeoxyglucose uptake and to explore the molecular mechanism of glycometabolism disorder in pancreatic cancer.3. To study the correlation between survival and flurodeoxyglucose uptake, to evaluate the value of PET/CT imaging in predicting prognosis of patients with pancreatic cancer.MethodsFrom Janurary 2011 to June 2013,50 patients with pancreatic cancer proved by pathology were examined by 18F-FDG PET/CT before planned resective pancreatic surgery. The SUVmax, clinical indexes, pathological characteristics and following-up information were retrospectively collected. The expression of Glut-1 was studied by immunohistochemistry. The correlation among these factors was analyzed.Results1. The SUVmax was 1.4-14.4, with the average of (5.44±2.88). SUVmax had no correlation to diabetes, Dmax, tumor location, CA19-9 level, TNM stage, histological differentiation and expression of Ki-67(p>0.05).2. Of all 50 pancreatic cancer patients,44 were positive for the expression of Glut-1. Meanwhile of all normal pancreatic tissue, none was positive for the expression of Glut-1. There were statistical differences between them. Glut-1 expression had no correlation to SUVmax(r=0.08). In the positive expression cases, SUVmax increased with the increased expression of Glut-1.3. Kaplan-Meier analysis showed that the six month and twelve month survival rates of A group(SUV<4) was higher than those of B group(SUV>4). Cox multi-factor analyses indicated that the TNM stage was one risk factor of long-term survivals(p =0.009<0.05), SUV might be closely related to long-term survivals(p=0.064). When patients who were analyzed for SUV were stratified according to other variables, FDG uptake was related to survival also after stratification for the following:age over 63 years (p=0.001) and stage Ⅰ to Ⅱ(p=0.030).Conclusion1. SUVmax has no correlation to diabetes, Dmax, tumor location, CA19-9 level, TNM stage, histological differentiation and expression of Ki-67.2. The expression of Glut-1 increase in pancreatic cancer, but it has no correlation to SUVmax. In the positive expression cases, the SUVmax increase with the increased expression of Glut-1.3. TNM stage and SUV are useful in predicting prognosis of patients with pancreatic cancer. Especially for patients who are over 63 years old or patients who are in the TNM Ⅱ stage, PET/CT should be used to assess prognosis and guide individual treatment.