The Effect Of Pre-Meal Chewing Gum On Blood Levels Of GLP-1 In Healthy Non-Obese Men

Objective We evaluated the effect of chewing on blood GLP-1 level by chewing sugarless gum, intended to explore the neural mechanisms of GLP-1 secretion regulation.Methods After fasting 12 hours,12 healthy male non-obese volunteers (18<BMI<30), were arranged to chew sugarless gum in a frequency of 80 times every 2 minutes, for total of half an hour. Blood samples were collected before the start of chewing and 5,10, 15,20,25 and 30 minutes after the start, respectively. Meanwhile satiety and hunger were evaluated from 0 to 100 at each time point.Results Compared with the control group, by chewing sugarless gum 80 times every 2 minutes, the satiety of the test group increased at 15,25 and 30 minutes after the beginning (p= 0.043, p= 0.014 and p= 0.018, respectively), blood GLP-1 level of the test group at 30 minutes was 49.6±20.3pmol/l, significantly higher than the control group(38.9±20.9 pmol/l, p= 0.031). There was no significant difference in the test group at each time point in GLP-1 levels. In the control group, compared to baseline, levels of GLP-1 at 15,25 and 30 minutes were significantly decreased (p= 0.042, p= 0.0214 and p=0.012, respectively). No significant differences in blood levels of glucose, insulin and GIP, and hunger were shown between groups.Conclusions Our study suggests, fasting chewing sugarless gum can increase satiety, and decrease the decline of GLP-1 levels.