| ObjectivesDyslipidemia is a major risk factor of cardiovascular disease. As the primary group of prevalent of cardiovascular disease, elderly population has both commonalities and particularities on pathogenesis, treatment and prevention strategies comparing with non-elderly people. To find out the trend of blood lipid in elderly with aging, we observed a relatively stable elderly population, and analyzed the general level, distribution features, dynamic changes and relationship with some common risk factors, and had further discussion the strategies of blood lipid regulation therapy and prevention and control of cardiovascular disease during senile period.MethodsWe analyzed the data of annual health check from The General Hospital of Tianjin Medical University Health Care Department from2011to2013, followed up the sequence of blood lipid on elderly in order to investigate the general level, abnormality features and dynamic changes of blood lipid in this elderly group and healthy elderly group. We also analyzed the relationship between lipid level and gender, age, blood pressure (BP), body mass index (BMI), uric acid (UA), fasting plasma glucose (FPG), and glycated hemoglobin Ale (HbAlc). By the way of questionnaire, to learn about the basic information of elderly, such as the lifestyle, past medical history, medication history, and analyzed the relationship between lipid level and cardiovascular disease risk factors, and also with some common underlying diseases.Results1. The average blood lipid level of this health screening groups of elderly cadre in2013were total cholesterol (TC)4.97±0.95mmol/L, triglycerides (TG)1.47±0.89mmol/L, high density lipoprotein cholesterol (HDL-C)1.39±0.39mmol/L, low density lipoprotein cholesterol (LDL-C)2.94±0.83mmol/L. The level of BMI, TC, TG and LDL-C increased with aging, and then decreased at the same age pointcut. The pointcut was50-59age group of male and60-69age group of female, was higher than the previous research in China of45-49age group. HDL-C level had a reverse pattern, decreased with aging and then increased at the same pointcut as above. The overall level of TC, TG, HDL-C and LDL-C of elderly group were higher than non-elderly group. In female level of TC, HDL-C were higher than male, TG and LDL-C level were higher than male after60year old and40year old.2. The average blood lipid level of healthy elderly were TC4.13-6.03mmol/L, TG0.65-2.01mmol/L, HDL-C1.09-1.85mmol/L, LDL-C2.20-3.82mmol/L, higher than general population, and all detected blood lipid level were higher in female than in male. Healthy elderly was account for22.1%of elder people and male lower than female, its ratio declined with aging. TC, LDL-C and HDL-C were higher but TG was lower in healthy elderly than in control group. There were some factors which influence the lipid level of elderly control group such as BMI, BP, UA, FPG and HBA1C. Affecting factors were fewer in healthy elderly group.3. The blood lipid level and abnormal ratio appeared declining trend in cadre examination group. The misbehavior in this population included:smoking, lack of physical exercises and snoring. The abnormal ratio of overweight and obesity, hypertension, hyperuricemia, dyslipidemia and hyperglycemia were higher. The total prevalence of chronic diseases was as high as account for69.7%, the top ten chronic diseases in sequence were hypertension, hyperuricemia, coronary heart disease(CHD), chronic obstructive pulmonary disease(COPD), stroke, osteoporosis, arrhythmia, diabetes mellitus, cerebral vascular disease, lower extremity arterial disease. Risk factors of CHD were history of hypertension, gout, abnormal glucose metabolism, diabetes mellitus, cerebrovascular, lower extremity arterial disease, autoimmune disease. Protective factors of CHD were high level of HDL-C, triglyceride and cholesterol lowering therapy.Conclusions1. In2013, this elderly cadres population of health check was a well-educated, professional urban resident population. The overall level of TC, TG, HDL-C and LDL-C of elderly group were higher than non-elderly group. The level of TC, TG, LDL-C and HDL-C changed regularly with aging, and the age pointcut was higher than the previous research in China. The abnormality ratio of overweight, obesity and dyslipidemia were higher than previous research. 2. We investigated the average level and general features of blood lipid in this urban living healthy retired cadres population. The total blood lipid level of healthy elderly was higher than general population, and also higher than the control elderly group except TG. Because HDL-C level in the healthy elderly group was significantly higher than the control group and maintained a high level in all age groups, we considered that sustained and stable high level of HDL-C may be an important feature of blood lipid in healthy elderly group. By comparison and analysis of related factors of blood lipid, we found that the lipid level of healthy elderly may be influenced by the level of BMI, UA, FPG, HBAlc and BP, although these factors were in the normal range of healthy elderly. Health managers should set up a well-focused lipid-lowering therapy for the high-risk groups based on different types of dyslipidemia.3. The blood lipid level and abnormal ratio appeared declining trend in this cadre group, showing people’s health-conscious increased gradually. The unhealthy lifestyle in this population was below the domestic level, but some major risk factors of cardiovascular diseases such as overweight, obesity, hypertension, hyperuricemia, dyslipidemia, hyperglycemia and the total prevalence of chronic diseases were higher than domestic population. We should develop health education programs according to the risk factors, and advocate healthy life-style and regular check-up, in order to control the chronic diseases, prevent the occurrence of cardiovascular disease. |
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