| Tumor is a serious disease hazard to human health. Early detection and diagnosis should be the key measure to tumor prevention and treatment. Currently, tumor generally diagnosed with obvious occupyinglesion or clinical symptoms,its early diagnosis mainly relies on imaging or pathology technologies. However, from the perspective of cancer biology, space occupying lesion may have not been the most early time of the cancer. So for the incidence of tumor control, it will be important to make a diagnosis and give treatment to the small early carcinoma.The existence of the tumor marker or its amount changes can explore the existence, nature, source or cell differentiation of the tumor, etc. According to this, we can classify, diagnose the tumor, and assess prognosis and guiding therapy for it. PSA and other tumor markers used in the cancer screening, they have an important value in early diagnosis, prognosis and treatment of tumor.From clinical practice, we find that quite a number of people only with tumor markers abnormal expression, but did not find the tumor lesions.The individualized diagnosis and treatment of Chinese medicine, concept of viewing the situation as a whole, overall adjustment means of prevention and control, and the early intervention which under the guidence of the concepts of preventive treatment have advantage to the treatment of this special phase.Through the early intervention effect by this treatment to the special period that PSA abnormal expression but without Prostate cancer lesions,this paper has discussed the early intervention effect and the advantages of the therapy that nourishing kidney yin,opening essence or water orifices and disintoxication to PSA abnormal expression,it is consisted by three parts that it is theoretical discussion, clinical efficacy observation and experimental study.Combinated the Chinese medicine theory and clinical practice,the part of the-oretical discussion has analysised the etiology, pathogenesis, pathogenic factors, disease location and potential changes of the special period for this disease, at the same time summarized its differential treatment. It proposed that dysfunctional organs, imbalance of yin and yang, the lack of healthy Qi,the pathogenic toxin stagnation of the qi, blood or fluid is the main etiology and pathogenesis of PSA abnormal expression, especially kidney yin deficiency, bladder gasification negative and pathogenic toxin accumulation can cause the disease.Its pathogenesis is complex, such as origin deficiency and excess in superficiality, mixture of deficiency and excess, and disease tendency changes fast are the charectersfor the disease, and it easily become a malignant tumor, so early intervention is necessary. The syndrome differentiation and treatment for PSA abnormal should put the macroscopic and microcosmic syndrome differentiation in combination, observate the position of body resistance deficiency, inspect the tide of healthy energy or pathogenic factors then treat by the supporting healthy energy to eliminate pathogenic factors method. Meanwhile, considering the anomaly characteristics of the PSA, timely treatment to prevent the tumor lesion formation, inhibit tumor’s development, and improve the quality of life. And then we establish the fundamental early intervention therapy that nourishing kidney yin,opening essence or water orifices and disintoxication method, and the basic characteristic of the method is "nourishing kidney yin, diuresis or dissolving blood stasis, detoxification to inhibit tumor growth".By the method as the main means, the clinical analysis section discussed the clinical curative effect after the method intervention in30patients, whose PSA abnormal but without prostate cancer. Results show that this treatment method has quick effect, and obviously improved symptoms.The PSA abnormal complete remission rate was93%, and the clinical symptoms effective rate was98%. During the treatment, there was no deterioration record and drugs cause side effects.Experiment study discussed the mechanism for the method to inhibite the PSA abnormal expression. Using RT-PCR, western-blot and ELISA techniques, puting the PSA which secreted by the human androgen dependent LNCaP cell as the research object, we have tested the changes of androgen receptor (AR) and the tumor suppressor gene P53which control the expression of PSA to reveal the possible molecular mechanism for this method decreased PSA expression.Experiment results show that, the therapy can be through different mechanisms to decrease PSA expression, such as reducingthe AR, up-regulation tumor suppressor gene P53or apoptosis gene Bax expression and so on.Moreover, this method has certain inhibitory effect on the proliferation of LNCaP cells in vitro, this can offers some experimental foundation for the legislation idea "detoxification to inhibition of tumor generation "of the treatment method.Through the above researches we get the following conclusion:kidney and bladder dysfunction, kidney yin deficiency and bladder gasification was bad, the pathogenictoxin stagnation of the qi, blood and fluid can cause PSA abnormal expression; Pathological changes of kidney yin deficiency and pathogenic toxin factors accumulation is closely related to this disease; the therapy of nourishing kidney yin,opening essence or water orifices and disintoxication which derived from clinical, based on the theory of Chinese medicine, and its curative effect is exact its an effective method for the early intervention of PSA abnormal expression; this method based on the legislation idea "nourishing kidney yin, diuresis ordissolving blood stasis, detoxification to inhibite tumor generation "has its theoretical, clinical and experimental basis; this therapy may from multi-angle, multi-level or comprehensive adjustment, through the possible mechanisms such as lowering the AR, increaseing tumor suppressor gene P53to realize the inhibitory effect for PSA abnormal expression. |
PDF Full Text Request