Clinical Research On Effects Of Huluanantai Upon POR Patients With Short Proaram Of IVF-ET

Objective:The objective of this thesis is to observe the effects of different TCM treatments interve the short program of IVF-ET treatment POR:to probe into the impact of different TCM treatments over POR’s ovary reserve function from basis endocrine, the exponent of ovary, BBT and clinical symptoms and so on;to probe into the effect of the program on POR’s responses when they enter a new cycle again from the numbers of taking eggs,the rate of fertility,the numbers of fertilized eggs, superior embryo rate, etc; to probe into the effect of different TCM treatments over POR’s the final progency results when they enter the new cycle from the biochemical pregnancy ratio,clinical pregnancy ratio;abortion ratio and so forth.Methods:The medical records chosen are divides into4groups:the group of Huluanantai,the group of Nuanchaoantai the group of Cupaiantai and the group of Antai according to the standards of diagnose and choosing. The patients in the group of Huluanantai continue taking the Huluantang and nuanchaobao3menstrual cycles after IVF-ET fail befor enter another IVF-ET’s cycle. They continue taking Cupaitang6fu from the day of entering IVF-ET’s cycles;and continue taking Antaitang12days from the day of embryo transfer.The patients in the group of Nuanchaoantai continue taking Nuanchaobao3menstrual cycles after IVF-ET fail befor enter another IVF-ET’s cycle. Other taking medicine methods are the same as the methods of the group of Huluanantai. The patients in group of Cupaiantai needn’t take medince before entering IVF-ET’s cycle, and begin to take Cupaitang on the day of ovulation and continue taking6fu; begin take Antaitang on the embryo transfer and continue taking12days. The patients in group of Antai begin to take Antaitang and continue taking12days. In order to learn the impact of the two programs over ovary reserve function, we collected the datas of groups of Huluanantai and Nuanchaoantai, such as basis endocrine,ovary basis bloodstream exponent,basis hole follicle number(AFC),the basis temperature(BBT),clinical symptoms and so on before they entered into IVF-ET’s cycle. In order to observe the different program’s ovary effect entering cycle once again to POR, we collected every group data of the number of taking the ovum, fertilization rate high grade embryo rates and the number of embryo transfer after they entered into IVF-ET’s cycle. In order to observe the different program’s pregnancy outcomes, we collected the biochemistry pregnancy rate, clinical pregnancy rate and abortion rate of every formsResults:1In the field of improvement ovary reserve function. Huluanantai scheme and Nuanchaoantai scheme all can reduce b-FSH rising, the difference curing the front and back notable,had statistics meaning (p<0.05),but Huluanantai scheme curative effect was more obvious, the difference had statistics meaning (p<0.01). The schemes of Huluanantai and Nuanchaoantai all have two-way to b-E2rising such or descending such adjusts an effect, but the Huluanantai scheme curative effect was more obvious, and the difference had statistics meaning (p<0.05) Huluanantai scheme and Nuanchaoantai scheme regimen in not significantly decrease elevated b-LH, but both can increase the too low b-LH, The difference was statistically significant (p<0.05).Clinical dfficacy of Huluanantai scheme was better than the latter, the difference was statistically significant (p<0.05). Huluanantai scheme ccould reduce too high FSH/LH obviously, the difference curing befor and after treatment was notable (p<0.01); the difference of Nuanchaoantai scheme was not obvious curing before and after (p>0.05),there was no statistics intention. Huluanantai scheme can improvement POR’s PI、RI、PSV obviously,the differernce had statistics meaning. And Nuanchaoantai scheme was contrary. The schemes of Huluanantai and Nuanchaoantai both ccould increase the number of POR’s AFC,the difference curing befor and after treatment was notable,had statistics meaning (p<0.05);and the scheme was obvious better than that Nuanchaoantai scheme, the difference was obviously, it had statistics meaning (p<0.05).In the field of POR’s ovary volume, the two schemes were not obviously,the difference curing before and after treatment was not notable (p>0.5). Huluanantai scheme could improve the thickness of POR’s endometria obviously, the difference curing before and after treatment was notable (p<0.05). In the field of improving BBT, the curative effect of Huluananti scheme was distinct, the difference curing before and after treatment was notable (p<0.01). And the Nuanchaoantai scheme’s curative effect not notable.2In the field of improving clinical symptom:Huluanantai scheme was more obvious than Nuanchaoantai scheme curative effect in the field of improvement the coulor of menstrual, acid bottom of the lumbar pain,the feel of tired, undersexed etc. But the difference was not notable after statistics treatment (p>0.05).May be connected with sample book amounts for limited. So to need the amounts increasing a sample book in research the days to come. Being worth pointing out especially, there were2natural regular patient gestation in A scheme, account for5%of group Huluanantai, however being sample book was limited, the difference of natural2schemes pregnancy rate was not notable afer statistics (p>0.05), there was no statistics significance. In the improvment POR’s deficiency of the kidney syndrome the2schemes have the fine curative effect equally after statistics handles the clinical syndrome integrates, the difference curing before and after treatment was notable (p<0.01);clinical syndrome curative effect difference was notable (p<0.05),the Huluanantai scheme curative effect was obvious better than Nuanchaoantai scheme.3In the field of the number of obtain the ovum,fertilization rate, high grade embryo rates and the number of transplant after entering cycle. Huluanantai schemes、Nuanchaoantai scheme and Cupaiantai scheme were compared with each other fetching an ovum difference being notable (p<0.01),the difference was not notable in the number of transplanting. Huluanantai scheme was obvious better than the other2schemes, the difference was notable (p<0.04),Nuanchaoantai scheme and Cupaiantai scheme difference were not notable (p>0.05, there was no statistics significance.3schemes fertilization rate difference was notable in the period (p<0.01), there was statistics significance. The schemes fertilization rate overtops Huluanantai schemes obviously2grows a scheme other. The difference was notable (p<0.01),Nuanchaoantai scheme and Cupaiantai scheme difference weree not notable (p>0.05), there was no statistics significance. The differernce of quality embryo rate of the3schemes was not notable (p>0.05), there was no statistics significance. In the field of pregnancy outcome after embryo transfer:4.1The difference of the three schemes is notable in the field of biochemistry pregnancy rate and clinical pregnancy rate (p<0.05),there was statistics significance. In the biochemistry pregnancy rate, Huluanantai scheme and Nuanchaoantai scheme difference aren’t notable (p<0.05),there wasn’t statistics significance. But Huluanantai scheme and another two kinds scheme comparison difference were all notable (p<0.05) In the field of clinical pregnancy rate, Huluanantai scheme and Nuanchaoantai schemes and Cupaiantai scheme difference were not notable (p>0.05), there wasn’t statistics significance. But it and Antai scheme difference is notable(p<0.05),there was statistics sifnificance.4.2The4schemes abortion rate difference was not notable (p>0.05)Conclusion:1Huluanantai scheme cures POR biochemistry pregnancy rate and clinical pregnancy rate than C scheme can have an effect to improve the scheme more. Cupaiantai scheme and Yangtai scheme curative are relatively poor.2TCM participation IVF-ET cures optimum POR opportunity ought to begin from entering cycle. This can improve the POR’s ovarian reserve function and endometrial receptivity, so to make a good foundation for the POR entering cycle again. After entering the cycle or (and) embryo transfer rear beginning to adopt TCM to assist the cffect treating to take second place.3Nuanchaobao diet can improve the POR’s ovarian reserve function and endometrial reccptivity.4Bushenjianpi therapy can be nursed XIANTIAN to health by nourishing HOUTIAN, improve POR’s ovarian reserve function, increase their tate of oocytes in ovulation induction, improve their biochemical pregnancy rate and clinical pregnancy rate.5"Antaiqianyi"thought and luteal support therapy of Western Midicine Different approaches but equally satisfactory results, they are to strengthen the function of endometrial’s SHETAI and ZAITAI and NATAI and enhancement of endometrial receptivity, so can effectively improve the POR’s pregnancy rate, reduce the rate of abortion.