The Research On The Anti-aging Effects Of Xiaochaihu Decoction

Skin aging is divided into two types:internal factors increas ed with age, resulting in the physiological aging, also known as na tural aging, it is synchronized with the aging of the body; environm ental factors such as sunlight and long-term repeated ultraviolet radiation, smoking, thephysical and chemical factors that stimul atesuch as cold, dry the skin caused by aging. Due to environmental factors, UV is the most important factors tocause skin aging, als o known as photoaging of the skin.Photoaging and natural aging on the clinical manifestations ar e different, leading to skin natural aging and photoaging reasons a re not the same, but due to schedule the causes and the natural a ging of superposition, it is difficult to completely separate the t wo, a cleardistinction between the results of skin aging can be de scribed as natural aging and photoaging together. Based on this, we believe that from the two-pronged approach toprevent and dela y the aging of the skin, to take reasonable and effective measure s in a comprehensive way, the emphasis on prevention and nursin g, in order to achieve the purpose of delay skin aging.Modern research showed that the active oxygen species ROS ofe xcess produce skin natural aging and1ight aging all have a closeth e connection, so the development of efficient and safe ofantioxid ants to clearactive oxygen from the skin of natural agingand ligh t aging two aspects of starting, fully integrated delay theeffectiv emeans of skin aging.Since the "Nei Jing", the ancient physicians has long been re cognized that the life course of people from chi ldhooddevelopment t o middle-aged, with the five internal organsgradually Chong Shen g body gradually prosperity of the process. Human aging is the deve lopment of the various organs of the bodyare the five internal orga ns function decline is the root causesleading to senescence.Traditionally Chinese medicine on aging theory, has beenspleno renal two dirty placed on the primacy of the aging. Kidney, the splee nhas become the primary means of ancient physiciansTotalesenili ty. However, the spleen and kidney is important, can not ignore th e function and role of other organs. In addition to thespleen, kidn ey, aging of the body’s five internal organs of the liverhave a c lose relationship. Liver stagnation and Spleen and kidneyof the b asis of a close relationship with the aging. Liver, the Chinese in the side ", liver and facial relationship is very close, a lot of fa ce aging performance and liver function disorders related to, stud ythe relationship between the liver and skin aging is particular ly important.Chinese medicine believes that skin aging and functionalimba lance of the lung, spleen, kidney three dirty close. We believe th at in addition to the dirty outside of the lung, spleen, kidney, li verand skin aging is closely related to. Liver controlling dispe rsionisan important guarantee of the liver has the beauty and sen ility role; the liver and the main reservoir of blood so that bloo d theChongsheng is facial skin be Ruyang. Regulating the liver but also promote the operation and function of the stomach, so that bl oodbiochemical active soil chinensis and up ". The blood toChongshe ng you skin moist, the face is not old.Xiaochaihu decoction has the notable effects of soothing liver and invigorating spleen, as well as regulating Qi and blood. It is widly applied in clinic to treat various related diseases in traditional Chinese Medicine. However, the novel application and scientific research of Xiaochaihu decoction on anti-aging and cosmetology remains unclear. Therefore, we focused to demonstrate the mechanisms of skin aging, and investigate the correlation of the liver and the spleen with the sking aging by Xiaochaihu decoction. The results may uncover useful approaches for Xiaochaihu decoction, and the important practical significance and value of clinical applications.Modern medicine believes that skin aging is mostly associate d with free radical damage is directly related to ultraviolet ra diationcan be induced to produce high concentrations of reactive oxygen species (ROS), the formation of melanin radicals and other c losely related. UV and visible light irradiation can increase the concentration of radicals in the melanin. Therefore, the natural a ging of skin photoaging and skin whitening and free radicals areins eparable, if you can find a single herb or prescription with theeffi cient removal of free radicals or inhibit free radical generation can be achieved delay skin aging, so that the skin whiteningpurpo ses.Xiaochahu decoction modern pharmacology studies have report edmore clear immunomodulatory, anti-cancer,anti-inflammatoryrol e of enhanced non-specific immune function, inhibition ofallergi c and anti-liver injury, the Japanese scholar shows that Xiaochahu decoction has a dose-dependentclearance·OH (hydroxyl radicals) th e role of Huang and otherstudy found that Xiaochahu decoction ca n significantly improve theD-galactoseinduced subacute agingmo del rat serum and hippocampus, SOD activity and reduced MDA and my ocardialLPFthe content. That Xiaochahu decoction may be antioxid ant, reducing free radical damage, with some anti-aging effects. T hus, we speculate that the Xiaochahu decoct ion may haveant ioxidant, anti-skin aging effects by scavenging free radicals.In this study, the ability to clear the DPPH,O2-·,·OH radical sthrough the observation of Xiaochahu decoction decoction results show that Xiaochahu decoction direct removal of these threeradi cals, and the clearance rate was a significant dose-related, tha t has strong ant ioxidant activity. Organism antioxidant, is thepos sibility of efficient removal of O2-, can effectively reduce the fo rmation of the body more toxic·OH. Xiaochahu decoction antioxida nt and free radical scavenging capacity and currently known anti-oxidant vitamin E quite. Prompted Xiaochahu decoction is a strong na tural free radical scavengers and ant ioxidants. The possible mech anism of i tsantioxidant play off the DPPH and quenching of O2-·,·OH radicals, enhance the antioxidant capacity related to the role.Delay skin aging, skin whitening and moisturizing is a hot iss ue forthe field of skin care, skin whitening, how to reduce pigment ationhas become a widespread concern in the world’s problems. On th e basis of the foregoing experiments, we further study thewhitening effect of Xiaochahu decoction, ancient square ofmelanoma cells an d affect melanogenes is mechanism to use toexpand the scope of appli cation of Xiaochahu decoction.This part of the study by forming cells in melanoma cells andm elanoma cells and keratinocytes co-culture system to detect Xiaoc hahu decoction on the proliferation of melanoma cells, tyrosinase activity and melanin synthesis, the results show that the small diesel Xiaochahu decoction on tyrosinase activity inmelanoma cel1s co-cultured cells, melanocytes synthesis in a dose-dependent in hibition, the concentration of drugs and control groups were sign if icant differences (p<0.05, orp<0.01); Xiaochahu decoction fo r tyrosinase act ivity in melanoma cells, the inhibition of melanoge nesis and its co-cultured cellsmelanogenesis and tyrosinase activi ty inhibition no difference (P>0.05). The results of this study s how that Xiaochahu decoction inhibits the tyrosinase activi ty was stronger in itsinhibit ion of melanin synthesis, suggesting Xiaoch ahu decoction may be mainly through the inhibition of tyrosinase activity to reduce melanocyte synthesis purpose. Whitening withth e currently accepted standard material arbutin compared with the bet ter whitening effect.