Mechanism Research On Invigorating Kidney Qi Method Intervention The Level Of Sex Hormones And Sex Hormone Receptor Expression Of Elderly Hypetrension Kidney-Qi Deficiency Syndrome

This study comes from the tutor Guo Weixing professor of the National NaturalScience Fund Project (NO.30873247)" kidney tonifying herbs intervention of elderlyhypertension kidney-qi deficiency syndrome sex hormone receptor expression and controlmechanism research ".Objective: Explore the features of sex hormone and sex hormone receptor expressionprofiles Which is closely related to the elderly hypertension kidney-qi deficiency syndrometo find the elderly hypertensive kidney-qi deficiency syndrome and sex hormonemetabolism and receptor expression in abnormal relationship between. Study of the elderlyhypertension patients with deficiency of kidney-qi sex hormone level and its receptorexpression intensity changes by the Invigorating kidney qi method before and afterintervention, in order to determine the Yi Shen Antihypertension Granule to intervene inthe disease of sex hormone, sex hormone receptor level on the targets and mechanisms ofaction. At the same time to explore the Yi Shen Antihypertension Granule on this type ofessential hypertensive patients clinical efficacy, for invigorating kidney qi method intreatment of elderly hypertensive disease and provide a theoretical basis. Method:Collection of the elderly hypertension kidney-qi deficiency syndrome in patients with60people cases (male30, female30) into the kidney deficiency group, the elderlyhypertensive liver-fire ascending syndrome in patients with60cases (male30, female30)into the liver-fire ascending groups, healthy older adults with60cases (male30, female30) incorporated the healthy elderly group. Using electrochemiluminescenceimmunoassay for detection of T, E2, FSH, LH and serum sex hormone index and usingflow cytometric assay for detection of ER beta, AR and sex hormone receptor index. Onone hand, observation of the three groups of subjects of sex hormone and sex hormone receptor expression intensity differences. On the other hand, Yi Shen AntihypertensionGranule on kidney deficiency patients for intervention patients were observed before andafter treatment, the changes of sex hormone levels, sex hormone receptor expressionintensity changes and clinical curative effect. Result: Compared to healthy elderly subjects,the elderly hypertension kidney-qi deficiency syndrome in patients with sex hormonemetabolism disorder and the expression of sex hormone receptor abnormalities, the mainmanifestations of male patients with serum T, E2levels drop, serum FSH, LH level andT/E2ratio increased, peripheral blood ER beta, AR expression intensity and female patientswith serum E2level decreased, the levels of serum FSH and T/E2ratio increased,peripheral blood ER beta, AR expression intensity. Invigorating kidney qi method not onlyis able to reverse hypertension kidney-qi deficiency syndrome in patients with changes ofsex hormone levels, bidirectional regulation of sex hormone levels, and can significantlyimprove such patients with sex hormone receptors expression intensity, but also caneffectively alleviate clinical symptoms, blood pressure. Conclusion: Sex hormonemetabolism and receptor expression may be abnormal in the elderly hypertensionkidney-qi deficiency syndrome of the occurrence and development of pathological basis.Serum sex hormones and sex hormone receptors in peripheral indicators indicators can beused as a diagnosis of the elderly hypertension kidney-qi deficiency syndrome withmodern science index. Yi Shen Antihypertension Granule in treatment of hypertension inthe elderly of kidney-qi deficiency syndrome effective compound. Invigorating kidney qi isa method of prevention and treatment of the elderly hypertension kidney-qi deficiencysyndrome, regulate the level of sex hormone and sex hormone receptor expression method.