Statistical Analysis For Longitudinal Data With Finite Mixture Correlation Matrices

The generalized estimating equations (GEE) method has been widely used to analyze longitudinal data since it was proposed by Liang and Zeger (1986). It is well known that the efficiency of the GEE estimator can be seriously affected by the choice of the working correlation matrix(Wang and Carey,2003). To address the as-sociated misspecification issue, we propose an estimator called mix-GEE based on a finite mixture model for the working correlation. Under mild regularity conditions, the mix-GEE estimator is consistent, asymptotically normal, and asymptotically efficient if data are from a Gaussian mixture model. An important feature of the mix-GEE method is that it guarantees the positive definiteness of the estimated working correlation matrix if either the AR(1) or exchangeable structure is in-cluded. It is numerically more stable and displays a better finite sample efficiency than the hybrid GEE method. The value of our method is further demonstrated by simulation studies and data examples.