The Research On Pulmonary Regulation And Rebuild In Chronic Obstructive Pulmonary Disease

Rooting in clinic,the research expounds the occur mechanism and new means of therapy in Chronic obstructive pulmonary disease(COPD). That entry for pulmonary governing management and regulation. Its for the sake of abundance therapeutics of Chinese Medicine and settle problem of clinic and service for human health.Pulmonary governing management and regulation is lung that regulate Qi, Blood, and Water. It has stabilization and harmony with self-environment for the balance.It based on probe into theory. Pulmonary governing management and regulation is sum up mostly physiological function of highness. Basic pathological mechanism of COPD is loss of governance of the pulmonary. It represents Deficiency of Qi, Phlegm and Blood stasis. Phlegm and blood stasis obstructing the Pulmonary of COPD is representative of loss of governance of the pulmonary in phase of Pulmonary arterial hypertension (PAH). It advances the ways of reconstruction of pulmonary regulation what is remedy of supplement QI, resolving phlegm and removing blood stasis. Triangle theory of Pulmonary system is coming into being.In animal experiments, establishing COPD animal model of phlegm and blood stasis obstructing the Lung. Animal model was giving Qibai Pingfei Capsule,Observing Rat lung function, Mean pulmonary arterial pressure, Right ventricular hypertrophy index, Blood gas analysis and Morphological changes of heart and lung tissue of before and after experiment. And comparing the difference efficacy among Qifai Pingfei capsule, TMP and Nifedipine.In clinical study, Such items as interleukin-1(IL-1),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),hyaluronic acid(HA), laminin (L N), procollagen typeⅢpeptide(PCⅢ), and so on in the sera of patients,observing those changes. Comparing the curative effect among Qibai Pingfei capsule, and Nifedipine.The research indicates:(1) Manifest of phlegm and blood stasis obstructing the Lung in COPD animal model accords with PAH.(2) Phlegm and blood stasis obstructing the Lung in COPD animal model is succeed.(3) Remedy of supplement QI, resolving phlegm and removing blood stasis has the effect on improving lack oxygen, lowing the space of airway remodeling, falling PAH, decreasing symptom, improving pulmonary function, increasing the quality of life of COPD. (4) Basic pathological mechanism of COPD is loss of governance of the pulmonary. The mechanism of reconstruction of pulmonary probability anti-inflammatory, lowing the course of airway remodeling, restricted remodeling of pulmonary blood vessel, regulating the balance of ET,NO,CGRP, affecting stretch and contract function of pulmonary blood vessel, consequently falling PAH, improving thickening of right ventricl and pulmonary function.(5) Applying remedy of supplement Qi, resolving phlegm and removing blood stasis for reconstruction of pulmonary could interdiction progress of COPD. It significance of bring COPD to PAH and chronic pulmonary heart disease...