| Alcoholic fatty liver (AFL) is the result of alcohol intake caused by lipid accumulation in liver cells more than 5% of liver wet weight of liver. it is the most common clinical For clinical treatment of this study provides a new way and method, is worthy of further research and extension. It is most early alcoholic liver disease (ALD) one. In China, alcohol-induced liver disease has become second cause of hepatitis, and along with increasing people's living standards, increasing the number of alcohol, alcoholic liver disease are rapidly increasing, it has become another serious public issue. In addition to modern medical treatment of alcoholism, there is no specific therapy without symptomatic treatment, In view of this status, under the guidance of our instructors, we research on alcoholic fatty liver theoretical, clinical and experimental problems. from the four aspects of a more detailed and systematic study.The first part was to explore traditional Chinese medicine theory. Firstly, the alcohol made the occurrence of fatty liver and physical endowments, and also link to weak spleen and stomach, excessive drinking, diet and other factors. The weakness and diet irregularly may affect the occurrence of the disease, and the prognosis, while excessive drinking is the direct cause of this disease. Secondly, spleen deficiency and loss of transportation is the intrinsic disease-oriented basis, phlegm and blood stasis among pathological changes became the key to this disease, loss of health delivery spleen, liver qi catharsis deficiency, heat of spleen and stomach, endogenous phlegm, qi-stagnancy and blood stasis, which eventually led to stagnation of qi, phlegm, blood stasis, plot in flank, disease in the liver and spleen, and kidney-related. Its pathogenesis can be summarized as loss of liver qi catharsis, blood stasis; spleen dysfunction, Shenqi deficiency. Third, a help for the treatment of spleen Huazhuo Huoxue Dafa, the disease is asthenia in origin and not asthenia in superficiality, it surely should tonify spleen, activate blood circle and resolve the phlegm.The second part of clinical research. Objective: To observe the effects of SilibinMeglumine Tablets with Xiaozhi Huoxue treating alcoholic fatty liver (AFL). Methods: 89 cases of alcoholic fatty liver patients were randomly divided into three groups, which combines group 1, Western and Chinese medicine treatment group 29 cases, group 2, 30 cases of Chinese medicine group, group 3, 30 cases of western medicine group, three groups of patients were received treatment combined with a variety of oral vitamin. Group1 with Western medicine and Huoxue Xiaozhi liquor, group2 was given Huoxue Xiaozhi alone; group3 SilibinMeglumine Tablets. And evaluate the efficacy of three groups. Results: The combination of Chinese and Western medicines clinically cured 29 cases of group 12 cases, 15 cases of effective and ineffective in 2 cases, total effective rate of 93.1%. Chinese medicine in 30 cases of group six cases of clinically cured, 12 cases of valid and invalid in 12 cases, total effective rate of 60.0%. Western medicine group of 30 cases of clinical cure in 6 cases, 11 cases of valid and invalid in 13 cases, total effective rate of 56.7%. Efficient compared three groups there was a significant difference significance, P <0.05. Conclusion: group1 was comprehensively effective than western medicine and Chinese medicine alone, with significant improvement in clinical symptoms and reduce the effects of blood lipids.The third part is about experimental study. Objective: To investigate the mechanism of Xiaozhi Huoxue liquor combined with SilibinMeglumine treating alcoholic fatty liver. Methods: rats with alcoholic fatty liver were randomly divided into normal control group, the experimental model group, treatment group of Chinese medicine, Western medicine in the treatment group and western medicine combined group, respectively, observed rat serum lipids, liver body weight ratio liver pathological changes, insulin resistance and leptin. Results: SilibinMeglumine combined with Xiaozhi Huoxue liquor can improve liver pathological circumstances in fatty liver rat model, reducing liver steatosis, lowering serum ALT, AST, TG and T-CH content, lowering weight, lowering leptin levels and improving insulin resistance index, we found that there was significantly superior to traditional Chinese medicine or Western medicine alone in the treatment group. Conclusion: Xiaozhi Huoxue liquor combined with SilibinMeglumine may be related to lipid lowering to reduce liver fat deposition, protecting liver cells and improve the microcirculation of the liver. The fourth part is about the progress of the treatment. From two aspects, Chinese medicine and Western medicine, in recent years many scholars and experts from different point of view and treatment of alcoholic fatty liver are reviewed. Modern medical treatment of alcoholic fatty liver in addition to alcohol, symptomatic treatment is concerned. Chinese medicine in treatment of alcoholic fatty liver, regardless of the treatment is implemented uptodate, differentiation or post-treatment drug treatment professionals have better efficacy, the initial indications of its potential advantages, comprehensive domestic and foreign alcoholic fatty liver study of the status, the current Chinese medicine alcoholic fatty liver treatment of clinical cases is lack of the bulk of the forward-looking research and methods of modern medical science (biochemistry, immunology, B-and even liver biopsy, etc.); in experimental studies it is need to develop a stable good wine liver model, compared observed single, or even repeat the same and so on. Therefore improving the clinical research norms as soon as possible, in-depth research carried out experiments, in particular the cellular level of research, clinical screening of good reproducibility, high efficacy of herbs and herbal pharmacology studies, on the basis of their active ingredients mentioned, simple clinical application of research and efficient new forms, is an urgent need for work.In our project of Huazhuo Huoxue tonifying spleen research, 89 cases in accordance with traditional Chinese medicine is divided into deficiency syndrome of phlegm and damp, heat and humid, stagnation of liver Qi, stagnation of Qi and blood stasis,phlegm and blood stasis, Yin deficiency. combined with B-ultrasound, we found that stagnation of liver Qi stagnation is the most prevalent, which 42 cases of alcoholic fatty liver, accounting for 47.2 percent. mild fatty liver, accounting for 57.1% of this type; syndrome of spleen deficiency and phlegm damp followed by 21 cases, accounting for 23.6 percent of the sample, moderate fatty liver, accounting for 81.0% of this type; syndrome of phlegm and blood stasis 10 cases, accounting for 11.2 percent of the total number, clinical to severe fatty liver, accounting for 60% of this type. All the cases accounted for more than 82.0 percent of the total number of samples. Other 16 cases, the less proportion. This shows that the vast majority of patients with AFL have a spleen deficiency Syndrome, Qi stagnation, phlegm, blood stasis disease factors. From the clinical efficacy, 19 cases in group 1 with effective fell into syndrome of liver depression qi stagnation, spleen phlegm and damp, hot and humid, liver qi stagnation and blood stasis, phlegm and blood stasis that traditional Chinese medicine "Xiaozhi Huoxue liquor" with loosening liver qi and tonifying spleen, Huazhuo Quyu effectiveness, the main indication for liver depression qi stagnation, spleen damp and phlegm, phlegm and blood stasis of AFL in particular, stagnation of liver Qi stagnation, blood stasis and spleen deficiency clinical efficacy in patients were good, and the effect of other type was not ideal. Treatment is of the essence of Chinese medicine, seizing the AFL in patients with clinical deficiency blood stasis of the basic pathogenesis of the evolution of the law, help to expose the Huazhuo Huoxue tonifying spleen, using traditional Chinese medicine to obtain a better clinical efficacy. This also prompted the importance of diagnosis.For clinical treatment, this study provides a new way and method, is worthy of further research and extension. |
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